"Phospholipase D" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme found mostly in plant tissue. It hydrolyzes glycerophosphatidates with the formation of a phosphatidic acid and a nitrogenous base such as choline. This enzyme also catalyzes transphosphatidylation reactions. EC 3.1.4.4.
MeSH Number(s)
D08.811.277.352.640.700.710
Concept/Terms
Phospholipase D- Phospholipase D
- Lecithinase D
- Phosphatidylcholine Phosphohydrolase
Below are MeSH descriptors whose meaning is more general than "Phospholipase D".
Below are MeSH descriptors whose meaning is more specific than "Phospholipase D".
This graph shows the total number of publications written about "Phospholipase D" by people in Harvard Catalyst Profiles by year, and whether "Phospholipase D" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 2 | 3 |
| 1995 | 3 | 0 | 3 |
| 1996 | 1 | 1 | 2 |
| 1997 | 2 | 0 | 2 |
| 1998 | 1 | 2 | 3 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 3 | 3 |
| 2002 | 0 | 4 | 4 |
| 2005 | 1 | 0 | 1 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 2 | 3 |
| 2009 | 2 | 2 | 4 |
| 2010 | 2 | 2 | 4 |
| 2011 | 2 | 0 | 2 |
| 2013 | 2 | 0 | 2 |
| 2015 | 2 | 0 | 2 |
| 2017 | 1 | 1 | 2 |
| 2018 | 1 | 1 | 2 |
| 2019 | 1 | 1 | 2 |
| 2020 | 3 | 0 | 3 |
| 2021 | 1 | 0 | 1 |
| 2023 | 1 | 0 | 1 |
Below are the most recent publications written about "Phospholipase D" by people in Profiles.
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Activity-based directed evolution of a membrane editor in mammalian cells. Nat Chem. 2023 07; 15(7):1030-1039.
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Activity-based, bioorthogonal imaging of phospholipase D reveals spatiotemporal dynamics of GPCR-Gq signaling. Cell Chem Biol. 2022 01 20; 29(1):67-73.e3.
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D-series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution. FASEB J. 2020 12; 34(12):15888-15906.
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Amyotrophic Lateral Sclerosis Modifiers in Drosophila Reveal the Phospholipase D Pathway as a Potential Therapeutic Target. Genetics. 2020 07; 215(3):747-766.
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Phospholipase D1 Ablation Disrupts Mouse Longitudinal Hippocampal Axis Organization and Functioning. Cell Rep. 2020 03 24; 30(12):4197-4208.e6.
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Clinical activity of programmed cell death 1 (PD-1) blockade in never, light, and heavy smokers with non-small-cell lung cancer and PD-L1 expression =50. Ann Oncol. 2020 03; 31(3):404-411.
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Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids. J Biol Chem. 2020 01 03; 295(1):263-274.
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Modulation of Lipid Metabolism by Celastrol. J Proteome Res. 2019 03 01; 18(3):1133-1144.
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A Molecular Target for an Alcohol Chain-Length Cutoff. J Mol Biol. 2019 01 18; 431(2):196-209.
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Impact of glycosylphosphatidylinositol-specific phospholipase D on hepatic diacylglycerol accumulation, steatosis, and insulin resistance in diet-induced obesity. Am J Physiol Endocrinol Metab. 2019 02 01; 316(2):E239-E250.