"Phenformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290)
Below are MeSH descriptors whose meaning is more general than "Phenformin".
Below are MeSH descriptors whose meaning is more specific than "Phenformin".
This graph shows the total number of publications written about "Phenformin" by people in Harvard Catalyst Profiles by year, and whether "Phenformin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
Year | Major Topic | Minor Topic | Total |
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1997 | 1 | 0 | 1 |
2006 | 0 | 1 | 1 |
2007 | 1 | 0 | 1 |
2010 | 0 | 1 | 1 |
2013 | 1 | 0 | 1 |
2014 | 1 | 0 | 1 |
2017 | 1 | 0 | 1 |
2018 | 1 | 0 | 1 |
2020 | 1 | 0 | 1 |
Below are the most recent publications written about "Phenformin" by people in Profiles.
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Catastrophic ATP loss underlies a metabolic combination therapy tailored for MYCN-amplified neuroblastoma. Proc Natl Acad Sci U S A. 2021 03 30; 118(13).
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Phenformin Promotes Keratinocyte Differentiation via the Calcineurin/NFAT Pathway. J Invest Dermatol. 2021 01; 141(1):152-163.
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Mitochondrial Complex I Activity Is Required for Maximal Autophagy. Cell Rep. 2018 08 28; 24(9):2404-2417.e8.
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Treatment of Pancreatic Cancer Patient-Derived Xenograft Panel with Metabolic Inhibitors Reveals Efficacy of Phenformin. Clin Cancer Res. 2017 Sep 15; 23(18):5639-5647.
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Phenformin Inhibits Myeloid-Derived Suppressor Cells and Enhances the Anti-Tumor Activity of PD-1 Blockade in Melanoma. J Invest Dermatol. 2017 08; 137(8):1740-1748.
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Phenformin Enhances the Efficacy of ERK Inhibition in NF1-Mutant Melanoma. J Invest Dermatol. 2017 05; 137(5):1135-1143.
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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis. Cell. 2015 Jul 30; 162(3):540-51.
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Metformin and phenformin deplete tricarboxylic acid cycle and glycolytic intermediates during cell transformation and NTPs in cancer stem cells. Proc Natl Acad Sci U S A. 2014 Jul 22; 111(29):10574-9.
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Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides. Nature. 2014 Apr 03; 508(7494):108-12.
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Phenformin enhances the therapeutic benefit of BRAF(V600E) inhibition in melanoma. Proc Natl Acad Sci U S A. 2013 Nov 05; 110(45):18226-31.