"Patch-Clamp Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.
Concept/Terms
Patch-Clamp Techniques- Patch-Clamp Techniques
- Patch Clamp Techniques
- Patch-Clamp Technique
- Technique, Patch-Clamp
- Techniques, Patch-Clamp
- Patch-Clamp Technics
- Patch Clamp Technics
- Patch-Clamp Technic
- Technic, Patch-Clamp
- Technics, Patch-Clamp
Whole-Cell Recording- Whole-Cell Recording
- Recording, Whole-Cell
- Recordings, Whole-Cell
- Whole Cell Recording
- Whole-Cell Recordings
Voltage-Clamp Techniques- Voltage-Clamp Techniques
- Technique, Voltage-Clamp
- Techniques, Voltage-Clamp
- Voltage Clamp Techniques
- Voltage-Clamp Technique
- Voltage-Clamp Technics
- Technic, Voltage-Clamp
- Technics, Voltage-Clamp
- Voltage Clamp Technics
- Voltage-Clamp Technic
Below are MeSH descriptors whose meaning is more general than "Patch-Clamp Techniques".
Below are MeSH descriptors whose meaning is more specific than "Patch-Clamp Techniques".
This graph shows the total number of publications written about "Patch-Clamp Techniques" by people in Harvard Catalyst Profiles by year, and whether "Patch-Clamp Techniques" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1995 | 0 | 15 | 15 |
| 1996 | 0 | 17 | 17 |
| 1997 | 0 | 22 | 22 |
| 1998 | 0 | 18 | 18 |
| 1999 | 0 | 28 | 28 |
| 2000 | 0 | 18 | 18 |
| 2001 | 0 | 25 | 25 |
| 2002 | 1 | 31 | 32 |
| 2003 | 0 | 32 | 32 |
| 2004 | 0 | 37 | 37 |
| 2005 | 2 | 37 | 39 |
| 2006 | 0 | 40 | 40 |
| 2007 | 1 | 36 | 37 |
| 2008 | 0 | 49 | 49 |
| 2009 | 1 | 44 | 45 |
| 2010 | 0 | 36 | 36 |
| 2011 | 0 | 38 | 38 |
| 2012 | 2 | 39 | 41 |
| 2013 | 2 | 32 | 34 |
| 2014 | 2 | 32 | 34 |
| 2015 | 2 | 25 | 27 |
| 2016 | 1 | 27 | 28 |
| 2017 | 1 | 19 | 20 |
| 2018 | 1 | 22 | 23 |
| 2019 | 0 | 16 | 16 |
| 2020 | 1 | 6 | 7 |
| 2021 | 2 | 8 | 10 |
| 2022 | 0 | 2 | 2 |
Below are the most recent publications written about "Patch-Clamp Techniques" by people in Profiles.
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The developmental changes in intrinsic and synaptic properties of prefrontal neurons enhance local network activity from the second to the third postnatal weeks in mice. Cereb Cortex. 2022 08 22; 32(17):3633-3650.
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Perinatal Opioid Exposure Results in Persistent Hypoconnectivity of Excitatory Circuits and Reduced Activity Correlations in Mouse Primary Auditory Cortex. J Neurosci. 2022 04 27; 42(17):3676-3687.
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a2d-2 is required for depolarization-induced suppression of excitation in Purkinje cells. J Physiol. 2022 01; 600(1):111-122.
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Retina-attached slice recording reveals light-triggered tonic GABA signaling in suprachiasmatic nucleus. Mol Brain. 2021 11 27; 14(1):171.
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Graded heterogeneity of metabotropic signaling underlies a continuum of cell-intrinsic temporal responses in unipolar brush cells. Nat Commun. 2021 10 07; 12(1):5491.
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Voltage Clamp Errors During Estimation of Concurrent Excitatory and Inhibitory Synaptic Input to Neurons with Dendrites. Neuroscience. 2022 05 01; 489:98-110.
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Frequency-Dependent Synaptic Dynamics Differentially Tune CA1 and CA2 Pyramidal Neuron Responses to Cortical Input. J Neurosci. 2021 09 29; 41(39):8103-8110.
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Modulation of the effects of class Ib antiarrhythmics on cardiac NaV1.5-encoded channels by accessory NaVß subunits. JCI Insight. 2021 08 09; 6(15).
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Auditory input enhances somatosensory encoding and tactile goal-directed behavior. Nat Commun. 2021 07 23; 12(1):4509.
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Recording Electrical Currents across the Plasma Membrane of Mammalian Sperm Cells. J Vis Exp. 2021 02 14; (168).