Harvard Catalyst Profiles

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Patch-Clamp Techniques

"Patch-Clamp Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.


This graph shows the total number of publications written about "Patch-Clamp Techniques" by people in Harvard Catalyst Profiles by year, and whether "Patch-Clamp Techniques" was a major or minor topic of these publication.
Bar chart showing 773 publications over 25 distinct years, with a maximum of 55 publications in 2008 and 2009
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.