Pantothenic Acid

"Pantothenic Acid" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A butyryl-beta-alanine that can also be viewed as pantoic acid complexed with BETA ALANINE. It is incorporated into COENZYME A and protects cells against peroxidative damage by increasing the level of GLUTATHIONE.

Descriptor ID

D010205

MeSH Number(s)

D02.478.520

D12.125.042.070.500

Concept/Terms

Below are MeSH descriptors whose meaning is more general than "Pantothenic Acid".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Imides [D02.478]
Pantothenic Acid [D02.478.520]
Amino Acids, Peptides, and Proteins [D12]
Amino Acids [D12.125]
Alanine [D12.125.042]
beta-Alanine [D12.125.042.070]
Pantothenic Acid [D12.125.042.070.500]

Below are MeSH descriptors whose meaning is related to "Pantothenic Acid".

Below are MeSH descriptors whose meaning is more specific than "Pantothenic Acid".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Pantothenic Acid" by people in Harvard Catalyst Profiles by year, and whether "Pantothenic Acid" was a major or minor topic of these publication.

Bar chart showing 12 publications over 7 distinct years, with a maximum of 3 publications in 2004

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	1	2	3
2011	0	2	2
2015	0	1	1
2019	2	0	2
2020	0	1	1
2021	1	0	1
2022	1	1	2

Below are the most recent publications written about "Pantothenic Acid" by people in Profiles.

PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Nature. 2022 08; 608(7921):192-198.

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Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nat Commun. 2022 04 20; 13(1):2158.

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Pantothenate and CoA biosynthesis in Apicomplexa and their promise as antiparasitic drug targets. PLoS Pathog. 2021 12; 17(12):e1010124.

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Fosmetpantotenate Randomized Controlled Trial in Pantothenate Kinase-Associated Neurodegeneration. Mov Disord. 2021 06; 36(6):1342-1352.

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Antimalarial pantothenamide metabolites target acetyl-coenzyme A biosynthesis in Plasmodium falciparum. Sci Transl Med. 2019 09 18; 11(510).

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The FOsmetpantotenate Replacement Therapy (FORT) randomized, double-blind, Placebo-controlled pivotal trial: Study design and development methodology of a novel primary efficacy outcome in patients with pantothenate kinase-associated neurodegeneration. Clin Trials. 2019 08; 16(4):410-418.

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Metabolic profiling by gas chromatography-mass spectrometry of energy metabolism in high-fat diet-fed obese mice. PLoS One. 2017; 12(5):e0177953.

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Evidence of Kinetic Cooperativity in Dimeric Ketopantoate Reductase from Staphylococcus aureus. Biochemistry. 2015 Jun 02; 54(21):3360-3369.

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Production of stable isotope-labeled acyl-coenzyme A thioesters by yeast stable isotope labeling by essential nutrients in cell culture. Anal Biochem. 2015 Apr 01; 474:59-65.

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Stable isotope dilution liquid chromatography/mass spectrometry analysis of cellular and tissue medium- and long-chain acyl-coenzyme A thioesters. Rapid Commun Mass Spectrom. 2014 Aug 30; 28(16):1840-8.

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