Pain Insensitivity, Congenital
"Pain Insensitivity, Congenital" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A syndrome characterized by indifference to PAIN despite the ability to distinguish noxious from nonnoxious stimuli. Absent corneal reflexes and INTELLECTUAL DISABILITY may be associated. Familial forms with autosomal recessive and autosomal dominant patterns of inheritance have been described. (Adams et al., Principles of Neurology, 6th ed, p1343)
Pain Insensitivity, Congenital
- Pain Insensitivity, Congenital
- Insensitivity, Congenital Pain
- Congenital Pain Insensitivity
- Congenital Analgesia
- Congenital Indifference to Pain
- Pain Indifference, Congenital
- Congenital Pain Indifference
- Congenital Pain Indifferences
- Analgesia, Congenital
Below are MeSH descriptors whose meaning is more general than "Pain Insensitivity, Congenital".
Below are MeSH descriptors whose meaning is more specific than "Pain Insensitivity, Congenital".
This graph shows the total number of publications written about "Pain Insensitivity, Congenital" by people in Harvard Catalyst Profiles by year, and whether "Pain Insensitivity, Congenital" was a major or minor topic of these publication.
To see the data from this visualization as text, click here.
|Year||Major Topic||Minor Topic||Total|
Below are the most recent publications written about "Pain Insensitivity, Congenital" by people in Profiles.
Structural analysis of TrkA mutations in patients with congenital insensitivity to pain reveals PLC? as an analgesic drug target. Sci Signal. 2022 04 26; 15(731):eabm6046.
A novel biallelic single base insertion in WNK1 in a Pakistani family with congenital insensitivity to pain. J Hum Genet. 2020 May; 65(5):493-496.
Biallelic truncating SCN9A mutation identified in four families with congenital insensitivity to pain from Pakistan. Clin Genet. 2016 12; 90(6):563-565.
Congenital insensitivity to pain and anhidrosis: Case report and review of findings along neuro-immune axis in the disorder. J Neurol Sci. 2016 Nov 15; 370:201-210.
Recurrent digital infections and osteomyelitis in monozygotic twins with congenital analgesia and compulsive onychophagia. J Child Neurol. 2014 Jul; 29(7):962-4.
Two novel SCN9A gene heterozygous mutations may cause partial deletion of pain perception. Pain Med. 2011 Oct; 12(10):1510-4.
Two novel mutations of SCN9A (Nav1.7) are associated with partial congenital insensitivity to pain. Eur J Pain. 2011 Mar; 15(3):223-30.
Emotional pain without sensory pain--dream on? Neuron. 2009 Jan 29; 61(2):153-5.
[Clinical and genetic aspects of congenital insensitivity to pain with anhidrosis]. Harefuah. 2005 Jun; 144(6):433-7, 453, 452.
An infant with primary tooth loss and palmar hyperkeratosis: a novel mutation in the NTRK1 gene causing congenital insensitivity to pain with anhidrosis. Pediatrics. 2003 Sep; 112(3 Pt 1):e237-41.