Orotidine-5'-Phosphate Decarboxylase

"Orotidine-5'-Phosphate Decarboxylase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Orotidine-5'-phosphate carboxy-lyase. Catalyzes the decarboxylation of orotidylic acid to yield uridylic acid in the final step of the pyrimidine nucleotide biosynthesis pathway. EC 4.1.1.23.

Descriptor ID

D009964

MeSH Number(s)

D08.811.520.224.125.450

Concept/Terms

Orotidine-5'-Phosphate Decarboxylase

Below are MeSH descriptors whose meaning is more general than "Orotidine-5'-Phosphate Decarboxylase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Lyases [D08.811.520]
Carbon-Carbon Lyases [D08.811.520.224]
Carboxy-Lyases [D08.811.520.224.125]
Orotidine-5'-Phosphate Decarboxylase [D08.811.520.224.125.450]

Below are MeSH descriptors whose meaning is related to "Orotidine-5'-Phosphate Decarboxylase".

Below are MeSH descriptors whose meaning is more specific than "Orotidine-5'-Phosphate Decarboxylase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Orotidine-5'-Phosphate Decarboxylase" by people in Harvard Catalyst Profiles by year, and whether "Orotidine-5'-Phosphate Decarboxylase" was a major or minor topic of these publication.

Bar chart showing 6 publications over 6 distinct years, with a maximum of 1 publications in 1993 and 2006 and 2010 and 2013 and 2017 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	1	0	1
2006	1	0	1
2010	0	1	1
2013	0	1	1
2017	1	0	1
2019	0	1	1

Below are the most recent publications written about "Orotidine-5'-Phosphate Decarboxylase" by people in Profiles.

Limits to Compensatory Mutations: Insights from Temperature-Sensitive Alleles. Mol Biol Evol. 2019 09 01; 36(9):1874-1883.

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Physiologic Medium Rewires Cellular Metabolism and Reveals Uric Acid as an Endogenous Inhibitor of UMP Synthase. Cell. 2017 Apr 06; 169(2):258-272.e17.

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Protein function annotation with Structurally Aligned Local Sites of Activity (SALSAs). BMC Bioinformatics. 2013; 14 Suppl 3:S13.

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Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate. J Am Chem Soc. 2010 May 26; 132(20):7018-24.

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A synthetic circuit for selectively arresting daughter cells to create aging populations. Nucleic Acids Res. 2010 May; 38(8):2727-35.

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Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach. Biochemistry. 2008 Jul 29; 47(30):7785-7.

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Formation and stability of a vinyl carbanion at the active site of orotidine 5'-monophosphate decarboxylase: pKa of the C-6 proton of enzyme-bound UMP. J Am Chem Soc. 2008 Feb 06; 130(5):1574-5.

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Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate. J Am Chem Soc. 2007 Oct 31; 129(43):12946-7.

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Counter-selectable marker for bacterial-based interaction trap systems. Biotechniques. 2006 Feb; 40(2):179-84.

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Nuclear localization and mitogen-activated protein kinase phosphorylation of the multifunctional protein CAD. J Biol Chem. 2005 Jul 08; 280(27):25611-20.

View in: PubMed

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