Harvard Catalyst Profiles

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No-Observed-Adverse-Effect Level

"No-Observed-Adverse-Effect Level" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

The highest dosage administered that does not produce toxic effects. The NOAEL will depend on how closely dosages are spaced (lowest-observed-adverse-effect level and no-observed-effect level) and the number of animals examined. The ultimate objective is usually to determine not the "safe" dosage in laboratory animals but the "safe" dosage for humans. Therefore, the extrapolation most often required of toxicologists is from high-dosage studies in laboratory animals to low doses in humans. (Casarett and Doull's Toxicology: The Basic Science of Poisons, 4th ed)


This graph shows the total number of publications written about "No-Observed-Adverse-Effect Level" by people in Harvard Catalyst Profiles by year, and whether "No-Observed-Adverse-Effect Level" was a major or minor topic of these publication.
Bar chart showing 26 publications over 13 distinct years, with a maximum of 8 publications in 2002
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.