"Neuropilin-1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Dimeric cell surface receptor involved in angiogenesis (NEOVASCULARIZATION, PHYSIOLOGICAL) and axonal guidance. Neuropilin-1 is a 140-kDa transmembrane protein that binds CLASS 3 SEMAPHORINS, and several other growth factors. Neuropilin-1 forms complexes with plexins or VEGF RECEPTORS, and binding affinity and specificity are determined by the composition of the neuropilin dimer and the identity of other receptors complexed with it. Neuropilin-1 is expressed in distinct patterns during neural development, complementary to those described for NEUROPILIN-2.
Concept/Terms
Neuropilin-1- Neuropilin-1
- Neuropilin 1
- Sema III Receptor
- Receptor, Sema III
- NRP1 Protein
- Semaphorin III Receptor
- A5 Antigen
- Antigen, A5
- Npn-1 Protein
- Npn 1 Protein
Below are MeSH descriptors whose meaning is more general than "Neuropilin-1".
Below are MeSH descriptors whose meaning is more specific than "Neuropilin-1".
This graph shows the total number of publications written about "Neuropilin-1" by people in Harvard Catalyst Profiles by year, and whether "Neuropilin-1" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 0 | 1 | 1 |
| 1998 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 3 | 3 |
| 2002 | 0 | 4 | 4 |
| 2003 | 1 | 0 | 1 |
| 2004 | 3 | 1 | 4 |
| 2005 | 3 | 2 | 5 |
| 2006 | 1 | 1 | 2 |
| 2008 | 0 | 2 | 2 |
| 2009 | 3 | 2 | 5 |
| 2010 | 1 | 2 | 3 |
| 2011 | 0 | 1 | 1 |
| 2012 | 1 | 1 | 2 |
| 2013 | 1 | 0 | 1 |
| 2014 | 6 | 2 | 8 |
| 2015 | 3 | 1 | 4 |
| 2016 | 2 | 1 | 3 |
| 2017 | 3 | 0 | 3 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 1 | 2 |
| 2021 | 0 | 1 | 1 |
Below are the most recent publications written about "Neuropilin-1" by people in Profiles.
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COVID-19 and Cardiovascular Disease: From Bench to Bedside. Circ Res. 2021 04 16; 128(8):1214-1236.
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NRP1 cripples immunological memory. Nat Immunol. 2020 09; 21(9):972-973.
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Regulatory T Cells License Macrophage Pro-Resolving Functions During Atherosclerosis Regression. Circ Res. 2020 07 17; 127(3):335-353.
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MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1. J Exp Clin Cancer Res. 2020 Jan 02; 39(1):3.
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Dual-Arm Nanocapsule Targets Neuropilin-1 Receptor and Microtubule: A Potential Nanomedicine Platform. Mol Pharm. 2019 06 03; 16(6):2522-2531.
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VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival. J Pathol. 2018 11; 246(3):311-322.
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Tumor Microvessel Density as a Potential Predictive Marker for Bevacizumab Benefit: GOG-0218 Biomarker Analyses. J Natl Cancer Inst. 2017 11 01; 109(11).
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Evidence for a Derangement of the Microvascular System in Patients with a Very Early Diagnosis of Systemic Sclerosis. J Rheumatol. 2017 08; 44(8):1190-1197.
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Neuropilin-1 mediates neutrophil elastase uptake and cross-presentation in breast cancer cells. J Biol Chem. 2017 06 16; 292(24):10295-10305.
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Downregulation of neuropilin-1 on macrophages modulates antibody-mediated tumoricidal activity. Cancer Immunol Immunother. 2017 Sep; 66(9):1131-1142.