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profileNeural Cell Adhesion Molecule L1

"Neural Cell Adhesion Molecule L1" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

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A member of the immunoglobulin superfamily of neuronal cell adhesion molecules that is required for proper nervous system development. Neural cell adhesion molecule L1 consists of six Ig domains, five fibronectin domains, a transmembrane region and an intracellular domain. Two splicing variants are known: a neuronal form that contains a four-amino acid RSLE sequence in the cytoplasmic domain, and a non-neuronal form that lacks the RSLE sequence. Mutations in the L1 gene result in L1 disease. Neural cell adhesion molecule L1 is predominantly expressed during development in neurons and Schwann cells; involved in cell adhesion, neuronal migration, axonal growth and pathfinding, and myelination.


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This graph shows the total number of publications written about "Neural Cell Adhesion Molecule L1" by people in Harvard Catalyst Profiles by year, and whether "Neural Cell Adhesion Molecule L1" was a major or minor topic of these publication.
Bar chart showing 35 publications over 19 distinct years, with a maximum of 8 publications in 2012
To see the data from this visualization as text, click here.