Harvard Catalyst Profiles

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Mutagenesis, Insertional

"Mutagenesis, Insertional" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.


This graph shows the total number of publications written about "Mutagenesis, Insertional" by people in Harvard Catalyst Profiles by year, and whether "Mutagenesis, Insertional" was a major or minor topic of these publication.
Bar chart showing 484 publications over 31 distinct years, with a maximum of 30 publications in 2013
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.