"Microsomes, Liver" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Closed vesicles of fragmented endoplasmic reticulum created when liver cells or tissue are disrupted by homogenization. They may be smooth or rough.
Below are MeSH descriptors whose meaning is more general than "Microsomes, Liver".
Below are MeSH descriptors whose meaning is more specific than "Microsomes, Liver".
This graph shows the total number of publications written about "Microsomes, Liver" by people in Harvard Catalyst Profiles by year, and whether "Microsomes, Liver" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 5 | 7 |
| 1994 | 2 | 4 | 6 |
| 1995 | 2 | 3 | 5 |
| 1996 | 3 | 3 | 6 |
| 1997 | 4 | 2 | 6 |
| 1998 | 0 | 5 | 5 |
| 1999 | 2 | 0 | 2 |
| 2000 | 0 | 3 | 3 |
| 2001 | 0 | 2 | 2 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 4 | 4 |
| 2005 | 0 | 1 | 1 |
| 2007 | 1 | 2 | 3 |
| 2009 | 2 | 4 | 6 |
| 2010 | 0 | 3 | 3 |
| 2011 | 1 | 4 | 5 |
| 2012 | 1 | 3 | 4 |
| 2013 | 2 | 2 | 4 |
| 2014 | 1 | 1 | 2 |
| 2015 | 1 | 4 | 5 |
| 2016 | 0 | 6 | 6 |
| 2017 | 0 | 3 | 3 |
| 2019 | 0 | 1 | 1 |
| 2020 | 0 | 6 | 6 |
| 2021 | 0 | 2 | 2 |
Below are the most recent publications written about "Microsomes, Liver" by people in Profiles.
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Structure-activity relationship study of THZ531 derivatives enables the discovery of BSJ-01-175 as a dual CDK12/13 covalent inhibitor with efficacy in Ewing sarcoma. Eur J Med Chem. 2021 Oct 05; 221:113481.
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Targeting Acute Myelogenous Leukemia Using Potent Human Dihydroorotate Dehydrogenase Inhibitors Based on the 2-Hydroxypyrazolo[1,5-a]pyridine Scaffold: SAR of the Biphenyl Moiety. J Med Chem. 2021 05 13; 64(9):5404-5428.
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Mechanisms of Herb-Drug Interactions Involving Cinnamon and CYP2A6: Focus on Time-Dependent Inhibition by Cinnamaldehyde and 2-Methoxycinnamaldehyde. Drug Metab Dispos. 2020 10; 48(10):1028-1043.
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Discovery of a series of benzopyrimidodiazepinone TNK2 inhibitors via scaffold morphing. Bioorg Med Chem Lett. 2020 10 01; 30(19):127456.
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Synthesis and evaluation of butein derivatives for in vitro and in vivo inflammatory response suppression in lymphedema. Eur J Med Chem. 2020 Jul 01; 197:112280.
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Design, synthesis and biological evaluation of novel O-carbamoyl ferulamide derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease. Eur J Med Chem. 2020 May 15; 194:112265.
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Synthesis and Characterization of Fluorine-18-Labeled N-(4-Chloro-3-((fluoromethyl-d2)thio)phenyl)picolinamide for Imaging of mGluR4 in Brain. J Med Chem. 2020 03 26; 63(6):3381-3389.
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Benzopyrimidodiazepinone inhibitors of TNK2. Bioorg Med Chem Lett. 2020 02 15; 30(4):126948.
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Structure-Guided In Vitro to In Vivo Pharmacokinetic Optimization of Propargyl-Linked Antifolates. Drug Metab Dispos. 2019 09; 47(9):995-1003.
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Derivatives of Natural Product Agrimophol as Disruptors of Intrabacterial pH Homeostasis in Mycobacterium tuberculosis. ACS Infect Dis. 2019 07 12; 5(7):1087-1104.