"Metformin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
Concept/Terms
Metformin- Metformin
- Dimethylguanylguanidine
- Dimethylbiguanidine
Below are MeSH descriptors whose meaning is more general than "Metformin".
Below are MeSH descriptors whose meaning is more specific than "Metformin".
This graph shows the total number of publications written about "Metformin" by people in Harvard Catalyst Profiles by year, and whether "Metformin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1991 | 2 | 0 | 2 |
| 1992 | 1 | 0 | 1 |
| 1993 | 1 | 0 | 1 |
| 1996 | 2 | 1 | 3 |
| 1998 | 0 | 1 | 1 |
| 1999 | 2 | 1 | 3 |
| 2000 | 2 | 2 | 4 |
| 2001 | 2 | 0 | 2 |
| 2002 | 3 | 1 | 4 |
| 2003 | 2 | 6 | 8 |
| 2004 | 6 | 3 | 9 |
| 2005 | 4 | 5 | 9 |
| 2006 | 1 | 6 | 7 |
| 2007 | 6 | 7 | 13 |
| 2008 | 3 | 9 | 12 |
| 2009 | 11 | 6 | 17 |
| 2010 | 7 | 7 | 14 |
| 2011 | 6 | 2 | 8 |
| 2012 | 10 | 13 | 23 |
| 2013 | 17 | 13 | 30 |
| 2014 | 24 | 12 | 36 |
| 2015 | 22 | 7 | 29 |
| 2016 | 26 | 10 | 36 |
| 2017 | 26 | 22 | 48 |
| 2018 | 18 | 15 | 33 |
| 2019 | 22 | 11 | 33 |
| 2020 | 17 | 6 | 23 |
| 2021 | 2 | 0 | 2 |
Below are the most recent publications written about "Metformin" by people in Profiles.
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Case 15-2021: A 76-Year-Old Woman with Nausea, Diarrhea, and Acute Kidney Failure. N Engl J Med. 2021 May 20; 384(20):1943-1950.
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Metformin Use Is Associated With Reduced Mortality in a Diverse Population With COVID-19 and Diabetes. Front Endocrinol (Lausanne). 2020; 11:600439.
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RIPK1 Promotes Energy Sensing by the mTORC1 Pathway. Mol Cell. 2021 01 21; 81(2):370-385.e7.
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Combining a High Dose of Metformin With the SIRT1 Activator, SRT1720, Reduces Life Span in Aged Mice Fed a High-Fat Diet. J Gerontol A Biol Sci Med Sci. 2020 10 15; 75(11):2037-2041.
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Metformin enhances protection in guinea pigs chronically infected with Mycobacterium tuberculosis. Sci Rep. 2020 10 01; 10(1):16257.
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Metformin versus insulin use for treatment of gestational diabetes and delivery by caesarean section: A nationwide Swedish cohort study. Eur J Obstet Gynecol Reprod Biol. 2020 Nov; 254:271-276.
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Effect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy. Diabetes Care. 2020 11; 43(11):2878-2881.
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Comparison of Outcomes With Metformin and Sulfonylureas in Chronic Kidney Disease. Mayo Clin Proc. 2020 07; 95(7):1551-1552.
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Obesity/Type 2 Diabetes-Associated Liver Tumors Are Sensitive to Cyclin D1 Deficiency. Cancer Res. 2020 08 15; 80(16):3215-3221.
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Sulfonylureas and Metformin Were Not Associated With an Increased Rate of Serious Bleeding in Warfarin Users: A Self-Controlled Case Series Study. Clin Pharmacol Ther. 2020 11; 108(5):1010-1017.