Metallothionein

"Metallothionein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A low-molecular-weight (approx. 10 kD) protein occurring in the cytoplasm of kidney cortex and liver. It is rich in cysteinyl residues and contains no aromatic amino acids. Metallothionein shows high affinity for bivalent heavy metals.

Descriptor ID

D008668

MeSH Number(s)

D12.776.556.670

Concept/Terms

Below are MeSH descriptors whose meaning is more general than "Metallothionein".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Metalloproteins [D12.776.556]
Metallothionein [D12.776.556.670]

Below are MeSH descriptors whose meaning is related to "Metallothionein".

Below are MeSH descriptors whose meaning is more specific than "Metallothionein".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Metallothionein" by people in Harvard Catalyst Profiles by year, and whether "Metallothionein" was a major or minor topic of these publication.

Bar chart showing 30 publications over 17 distinct years, with a maximum of 3 publications in 1998 and 2002 and 2007

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	1	2
1997	1	0	1
1998	1	2	3
1999	1	0	1
2000	1	1	2
2002	3	0	3
2004	0	1	1
2006	0	1	1
2007	1	2	3
2009	1	0	1
2012	0	1	1
2013	2	0	2
2014	2	0	2
2015	1	0	1
2016	1	1	2
2017	1	1	2
2018	2	0	2

Below are the most recent publications written about "Metallothionein" by people in Profiles.

Metallothioneins are neuroprotective agents in lysosomal storage disorders. Ann Neurol. 2018 02; 83(2):418-432.

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Single-cell RNA sequencing reveals metallothionein heterogeneity during hESC differentiation to definitive endoderm. Stem Cell Res. 2018 04; 28:48-55.

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Metallothionein Preserves Akt2 Activity and Cardiac Function via Inhibiting TRB3 in Diabetic Hearts. Diabetes. 2018 03; 67(3):507-517.

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Intercellular mRNA trafficking via membrane nanotube-like extensions in mammalian cells. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9873-E9882.

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Blockade of Metallothioneins 1 and 2 Increases Skeletal Muscle Mass and Strength. Mol Cell Biol. 2017 03 01; 37(5).

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Differential protein expression in metallothionein protection from depleted uranium-induced nephrotoxicity. Sci Rep. 2016 12 14; 6:38942.

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A Distinct Gene Module for Dysfunction Uncoupled from Activation in Tumor-Infiltrating T Cells. Cell. 2016 Sep 08; 166(6):1500-1511.e9.

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Metallothionein regulates intracellular zinc signaling during CD4(+) T cell activation. BMC Immunol. 2016 06 02; 17(1):13.

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Thermodynamics of Pb(ii) and Zn(ii) binding to MT-3, a neurologically important metallothionein. Metallomics. 2016 06 01; 8(6):605-17.

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Metallothionein deficiency aggravates depleted uranium-induced nephrotoxicity. Toxicol Appl Pharmacol. 2015 Sep 15; 287(3):306-15.

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