Melanocortins

"Melanocortins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Peptides derived from pro-opiomelanocortin (POMC) which can stimulate MELANOCYTES or CORTICOTROPHS. Melanocortins include ACTH; ALPHA-MSH; and other peptides such as BETA-MSH and GAMMA-MSH, derived from other fragments of POMC. These peptides act through a variety of MELANOCORTIN RECEPTORS to control different functions including steroidogenesis, energy homeostasis, feeding, and skin pigmentation.

Descriptor ID

D053486

MeSH Number(s)

D06.472.699.327.935.531

D06.472.699.631.525.600.531

D12.644.400.400.935.531

D12.644.548.365.935.531

D12.644.548.691.525.690.531

D12.776.641.650.405.935.531

Concept/Terms

Melanocortins

Below are MeSH descriptors whose meaning is more general than "Melanocortins".

Chemicals and Drugs [D]
Hormones, Hormone Substitutes, and Hormone Antagonists [D06]
Hormones [D06.472]
Peptide Hormones [D06.472.699]
Hypothalamic Hormones [D06.472.699.327]
Pro-Opiomelanocortin [D06.472.699.327.935]
Melanocortins [D06.472.699.327.935.531]
Pituitary Hormones [D06.472.699.631]
Pituitary Hormones, Anterior [D06.472.699.631.525]
Pro-Opiomelanocortin [D06.472.699.631.525.600]
Melanocortins [D06.472.699.631.525.600.531]
Amino Acids, Peptides, and Proteins [D12]
Peptides [D12.644]
Neuropeptides [D12.644.400]
Hypothalamic Hormones [D12.644.400.400]
Pro-Opiomelanocortin [D12.644.400.400.935]
Melanocortins [D12.644.400.400.935.531]
Peptide Hormones [D12.644.548]
Hypothalamic Hormones [D12.644.548.365]
Pro-Opiomelanocortin [D12.644.548.365.935]
Melanocortins [D12.644.548.365.935.531]
Pituitary Hormones [D12.644.548.691]
Pituitary Hormones, Anterior [D12.644.548.691.525]
Pro-Opiomelanocortin [D12.644.548.691.525.690]
Melanocortins [D12.644.548.691.525.690.531]
Proteins [D12.776]
Nerve Tissue Proteins [D12.776.641]
Neuropeptides [D12.776.641.650]
Hypothalamic Hormones [D12.776.641.650.405]
Pro-Opiomelanocortin [D12.776.641.650.405.935]
Melanocortins [D12.776.641.650.405.935.531]

Below are MeSH descriptors whose meaning is related to "Melanocortins".

Below are MeSH descriptors whose meaning is more specific than "Melanocortins".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Melanocortins" by people in Harvard Catalyst Profiles by year, and whether "Melanocortins" was a major or minor topic of these publication.

Bar chart showing 7 publications over 7 distinct years, with a maximum of 1 publications in 2009 and 2010 and 2012 and 2021 and 2022 and 2023 and 2024

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2009	0	1	1
2010	1	0	1
2012	1	0	1
2021	0	1	1
2022	0	1	1
2023	0	1	1
2024	1	0	1

Below are the most recent publications written about "Melanocortins" by people in Profiles.

Therapeutic Effects of Stimulating the Melanocortin Pathway in Regulating Ocular Inflammation and Cell Death. Biomolecules. 2024 Jan 31; 14(2).

View in: PubMed
Type 2 Diabetes Remission in Patients with Heterozygous Variants in the Leptin-Melanocortin Pathway after Roux-en-Y Gastric Bypass: A Matched Case-Control Study. Obes Surg. 2023 11; 33(11):3502-3509.

View in: PubMed
Prefrontal cortex melanocortin 4 receptors (MC4R) mediate food intake behavior in male mice. Physiol Behav. 2023 10 01; 269:114280.

View in: PubMed
Effects of Heterozygous Variants in the Leptin-Melanocortin Pathway on Transoral Outlet Reduction After Roux-en-Y Gastric Bypass: A Case-Control Study and Review of Literature. Obes Surg. 2023 04; 33(4):1284-1288.

View in: PubMed
Cardiovascular Risk and Diseases in Patients With and Without Leptin-Melanocortin Pathway Variants. Mayo Clin Proc. 2023 04; 98(4):533-540.

View in: PubMed
Effects of Heterozygous Variants in the Leptin-Melanocortin Pathway on Roux-en-Y Gastric Bypass Outcomes: a 15-Year Case-Control Study. Obes Surg. 2022 08; 32(8):2632-2640.

View in: PubMed
The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas. Int J Mol Sci. 2022 Apr 27; 23(9).

View in: PubMed
Oestrogen engages brain MC4R signalling to drive physical activity in female mice. Nature. 2021 11; 599(7883):131-135.

View in: PubMed
Deletion of Protein Kinase C ? in POMC Neurons Predisposes to Diet-Induced Obesity. Diabetes. 2017 04; 66(4):920-934.

View in: PubMed
Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus. PLoS One. 2015; 10(10):e0139462.

View in: PubMed

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