"Macrophage Activation" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The process of altering the morphology and functional activity of macrophages so that they become avidly phagocytic. It is initiated by lymphokines, such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants.
Concept/Terms
Macrophage Activation- Macrophage Activation
- Activation, Macrophage
- Activations, Macrophage
- Macrophage Activations
Below are MeSH descriptors whose meaning is more general than "Macrophage Activation".
Below are MeSH descriptors whose meaning is more specific than "Macrophage Activation".
This graph shows the total number of publications written about "Macrophage Activation" by people in Harvard Catalyst Profiles by year, and whether "Macrophage Activation" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 3 | 4 |
| 1994 | 0 | 4 | 4 |
| 1995 | 0 | 6 | 6 |
| 1996 | 2 | 4 | 6 |
| 1997 | 4 | 7 | 11 |
| 1998 | 0 | 3 | 3 |
| 1999 | 1 | 5 | 6 |
| 2000 | 4 | 5 | 9 |
| 2001 | 1 | 2 | 3 |
| 2002 | 6 | 5 | 11 |
| 2003 | 4 | 5 | 9 |
| 2004 | 2 | 11 | 13 |
| 2005 | 2 | 4 | 6 |
| 2006 | 2 | 7 | 9 |
| 2007 | 6 | 7 | 13 |
| 2008 | 6 | 7 | 13 |
| 2009 | 2 | 6 | 8 |
| 2010 | 1 | 12 | 13 |
| 2011 | 4 | 7 | 11 |
| 2012 | 2 | 7 | 9 |
| 2013 | 5 | 12 | 17 |
| 2014 | 7 | 12 | 19 |
| 2015 | 6 | 6 | 12 |
| 2016 | 10 | 7 | 17 |
| 2017 | 7 | 9 | 16 |
| 2018 | 6 | 11 | 17 |
| 2019 | 11 | 7 | 18 |
| 2020 | 6 | 16 | 22 |
| 2021 | 4 | 6 | 10 |
| 2022 | 4 | 3 | 7 |
Below are the most recent publications written about "Macrophage Activation" by people in Profiles.
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Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms. Circ Res. 2022 11 11; 131(11):873-889.
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Nuclear transport of STAT6 determines the matrix rigidity dependent M2 activation of macrophages. Biomaterials. 2022 11; 290:121859.
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RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice. Br J Pharmacol. 2022 09; 179(18):4500-4515.
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Blockade or Deletion of IFN? Reduces Macrophage Activation without Compromising CAR T-cell Function in Hematologic Malignancies. Blood Cancer Discov. 2022 03 01; 3(2):136-153.
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Macrophage polarization in hypoxia and ischemia/reperfusion: Insights into the role of energetic metabolism. Exp Biol Med (Maywood). 2022 06; 247(11):958-971.
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Definition of a mouse microglial subset that regulates neuronal development and proinflammatory responses in the brain. Proc Natl Acad Sci U S A. 2022 02 22; 119(8).
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SLAMF7 engagement superactivates macrophages in acute and chronic inflammation. Sci Immunol. 2022 02 11; 7(68):eabf2846.
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Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins. Molecules. 2021 Dec 28; 27(1).
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Signaling metabolite L-2-hydroxyglutarate activates the transcription factor HIF-1a in lipopolysaccharide-activated macrophages. J Biol Chem. 2022 02; 298(2):101501.
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Global characterization of macrophage polarization mechanisms and identification of M2-type polarization inhibitors. Cell Rep. 2021 11 02; 37(5):109955.