"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
MeSH Number(s)
A11.284.430.214.190.875.190.550
Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in Harvard Catalyst Profiles by year, and whether "Lysosomes" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 6 | 2 | 8 |
| 1993 | 1 | 6 | 7 |
| 1994 | 2 | 5 | 7 |
| 1995 | 4 | 6 | 10 |
| 1996 | 3 | 10 | 13 |
| 1997 | 2 | 2 | 4 |
| 1998 | 2 | 4 | 6 |
| 1999 | 2 | 6 | 8 |
| 2000 | 4 | 10 | 14 |
| 2001 | 2 | 6 | 8 |
| 2002 | 5 | 8 | 13 |
| 2003 | 6 | 3 | 9 |
| 2004 | 5 | 6 | 11 |
| 2005 | 7 | 10 | 17 |
| 2006 | 4 | 7 | 11 |
| 2007 | 4 | 6 | 10 |
| 2008 | 7 | 7 | 14 |
| 2009 | 3 | 12 | 15 |
| 2010 | 7 | 11 | 18 |
| 2011 | 5 | 13 | 18 |
| 2012 | 10 | 19 | 29 |
| 2013 | 9 | 22 | 31 |
| 2014 | 5 | 21 | 26 |
| 2015 | 14 | 11 | 25 |
| 2016 | 10 | 16 | 26 |
| 2017 | 14 | 12 | 26 |
| 2018 | 20 | 22 | 42 |
| 2019 | 22 | 24 | 46 |
| 2020 | 16 | 18 | 34 |
| 2021 | 11 | 18 | 29 |
| 2022 | 3 | 1 | 4 |
Below are the most recent publications written about "Lysosomes" by people in Profiles.
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Small molecule C381 targets the lysosome to reduce inflammation and ameliorate disease in models of neurodegeneration. Proc Natl Acad Sci U S A. 2022 03 15; 119(11):e2121609119.
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Lysosomal cystine mobilization shapes the response of TORC1 and tissue growth to fasting. Science. 2022 02 18; 375(6582):eabc4203.
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Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins. J Cell Sci. 2022 01 15; 135(2).
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Intravitreal gene therapy restores the autophagy-lysosomal pathway and attenuates retinal degeneration in cathepsin D-deficient mice. Neurobiol Dis. 2022 03; 164:105628.
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CYB561A3 is the key lysosomal iron reductase required for Burkitt B-cell growth and survival. Blood. 2021 12 02; 138(22):2216-2230.
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The CD22-IGF2R interaction is a therapeutic target for microglial lysosome dysfunction in Niemann-Pick type C. Sci Transl Med. 2021 12; 13(622):eabg2919.
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Presenilin/?-Secretase Activity Is Located in Acidic Compartments of Live Neurons. J Neurosci. 2022 01 05; 42(1):145-154.
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Glycosphingolipid metabolism and its role in ageing and Parkinson's disease. Glycoconj J. 2022 Feb; 39(1):39-53.
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Tubular lysosomes harbor active ion gradients and poise macrophages for phagocytosis. Proc Natl Acad Sci U S A. 2021 10 12; 118(41).
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Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy. Elife. 2021 09 29; 10.