"Lysosomes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A class of morphologically heterogeneous cytoplasmic particles in animal and plant tissues characterized by their content of hydrolytic enzymes and the structure-linked latency of these enzymes. The intracellular functions of lysosomes depend on their lytic potential. The single unit membrane of the lysosome acts as a barrier between the enzymes enclosed in the lysosome and the external substrate. The activity of the enzymes contained in lysosomes is limited or nil unless the vesicle in which they are enclosed is ruptured. Such rupture is supposed to be under metabolic (hormonal) control. (From Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)
MeSH Number(s)
A11.284.430.214.190.875.190.550
Below are MeSH descriptors whose meaning is more general than "Lysosomes".
Below are MeSH descriptors whose meaning is more specific than "Lysosomes".
This graph shows the total number of publications written about "Lysosomes" by people in Harvard Catalyst Profiles by year, and whether "Lysosomes" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 1 | 6 | 7 |
| 1994 | 2 | 5 | 7 |
| 1995 | 3 | 6 | 9 |
| 1996 | 3 | 9 | 12 |
| 1997 | 2 | 2 | 4 |
| 1998 | 2 | 3 | 5 |
| 1999 | 1 | 6 | 7 |
| 2000 | 4 | 10 | 14 |
| 2001 | 2 | 6 | 8 |
| 2002 | 5 | 8 | 13 |
| 2003 | 5 | 3 | 8 |
| 2004 | 5 | 7 | 12 |
| 2005 | 7 | 10 | 17 |
| 2006 | 4 | 6 | 10 |
| 2007 | 4 | 6 | 10 |
| 2008 | 7 | 7 | 14 |
| 2009 | 3 | 12 | 15 |
| 2010 | 6 | 12 | 18 |
| 2011 | 5 | 14 | 19 |
| 2012 | 9 | 19 | 28 |
| 2013 | 9 | 23 | 32 |
| 2014 | 5 | 21 | 26 |
| 2015 | 16 | 12 | 28 |
| 2016 | 11 | 19 | 30 |
| 2017 | 12 | 13 | 25 |
| 2018 | 17 | 21 | 38 |
| 2019 | 24 | 25 | 49 |
| 2020 | 16 | 20 | 36 |
| 2021 | 14 | 21 | 35 |
| 2022 | 4 | 11 | 15 |
| 2023 | 0 | 5 | 5 |
Below are the most recent publications written about "Lysosomes" by people in Profiles.
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A terpene nucleoside from M. tuberculosis induces lysosomal lipid storage in foamy macrophages. J Clin Invest. 2023 Mar 15; 133(6).
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mTOR gets greasy: lysosomal sensing of cholesterol. Cell Res. 2023 03; 33(3):189-190.
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Endosome and Lysosome Membrane Properties Functionally Link to ?-Secretase in Live/Intact Cells. Sensors (Basel). 2023 Feb 28; 23(5).
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mTOR signaling inhibition decreases lysosome migration and impairs the success of Trypanosoma cruzi infection and replication in cardiomyocytes. Acta Trop. 2023 Apr; 240:106845.
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A central role for regulated protein stability in the control of TFE3 and MITF by nutrients. Mol Cell. 2023 01 05; 83(1):57-73.e9.
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mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nat Metab. 2022 12; 4(12):1792-1811.
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Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis. Nat Commun. 2022 10 07; 13(1):5924.
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The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection. Science. 2022 10 07; 378(6615):eabn5648.
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Early lysosome defects precede neurodegeneration with amyloid-ß and tau aggregation in NHE6-null rat brain. Brain. 2022 09 14; 145(9):3187-3202.
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Coronavirus Lung Infection Impairs Host Immunity against Secondary Bacterial Infection by Promoting Lysosomal Dysfunction. J Immunol. 2022 10 01; 209(7):1314-1322.