Harvard Catalyst Profiles

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Loss of Heterozygosity

"Loss of Heterozygosity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.


This graph shows the total number of publications written about "Loss of Heterozygosity" by people in Harvard Catalyst Profiles by year, and whether "Loss of Heterozygosity" was a major or minor topic of these publication.
Bar chart showing 391 publications over 23 distinct years, with a maximum of 31 publications in 2004
To see the data from this visualization as text, click here.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.