"Loss of Heterozygosity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The loss of one allele at a specific locus, caused by a deletion mutation; or loss of a chromosome from a chromosome pair, resulting in abnormal HEMIZYGOSITY. It is detected when heterozygous markers for a locus appear monomorphic because one of the ALLELES was deleted.
Concept/Terms
Loss of Heterozygosity- Loss of Heterozygosity
- Heterozygosity Loss
- Allelic Loss
- Allelic Losses
- Heterozygosity, Loss of
Below are MeSH descriptors whose meaning is more general than "Loss of Heterozygosity".
Below are MeSH descriptors whose meaning is more specific than "Loss of Heterozygosity".
This graph shows the total number of publications written about "Loss of Heterozygosity" by people in Harvard Catalyst Profiles by year, and whether "Loss of Heterozygosity" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 |
| 1997 | 2 | 2 | 4 |
| 1998 | 8 | 17 | 25 |
| 1999 | 9 | 12 | 21 |
| 2000 | 5 | 17 | 22 |
| 2001 | 9 | 18 | 27 |
| 2002 | 8 | 13 | 21 |
| 2003 | 6 | 12 | 18 |
| 2004 | 9 | 19 | 28 |
| 2005 | 10 | 13 | 23 |
| 2006 | 4 | 16 | 20 |
| 2007 | 6 | 18 | 24 |
| 2008 | 3 | 11 | 14 |
| 2009 | 6 | 13 | 19 |
| 2010 | 7 | 10 | 17 |
| 2011 | 9 | 10 | 19 |
| 2012 | 4 | 6 | 10 |
| 2013 | 6 | 10 | 16 |
| 2014 | 2 | 9 | 11 |
| 2015 | 4 | 6 | 10 |
| 2016 | 3 | 12 | 15 |
| 2017 | 2 | 11 | 13 |
| 2018 | 2 | 11 | 13 |
| 2019 | 4 | 6 | 10 |
| 2020 | 3 | 5 | 8 |
| 2021 | 2 | 1 | 3 |
Below are the most recent publications written about "Loss of Heterozygosity" by people in Profiles.
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BRCA1/Trp53 heterozygosity and replication stress drive esophageal cancer development in a mouse model. Proc Natl Acad Sci U S A. 2021 10 12; 118(41).
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Bi-allelic loss-of-function variants in BCAS3 cause a syndromic neurodevelopmental disorder. Am J Hum Genet. 2021 06 03; 108(6):1069-1082.
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Breast tumours maintain a reservoir of subclonal diversity during expansion. Nature. 2021 04; 592(7853):302-308.
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Common germline-somatic variant interactions in advanced urothelial cancer. Nat Commun. 2020 12 03; 11(1):6195.
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Mechanism and significance of chromosome damage repair by homologous recombination. Essays Biochem. 2020 10 26; 64(5):779-790.
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Pervasive chromosomal instability and karyotype order in tumour evolution. Nature. 2020 11; 587(7832):126-132.
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Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes. Nat Med. 2020 10; 26(10):1549-1556.
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Monogenic and polygenic inheritance become instruments for clonal selection. Nature. 2020 08; 584(7819):136-141.
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Loss of heterozygosity of essential genes represents a widespread class of potential cancer vulnerabilities. Nat Commun. 2020 05 20; 11(1):2517.
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Patterns of chromosome 18 loss of heterozygosity in multifocal ileal neuroendocrine tumors. Genes Chromosomes Cancer. 2020 09; 59(9):535-539.