Locus Control Region

"Locus Control Region" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A regulatory region first identified in the human beta-globin locus but subsequently found in other loci. The region is believed to regulate GENETIC TRANSCRIPTION by opening and remodeling CHROMATIN structure. It may also have enhancer activity.

Descriptor ID

D019901

MeSH Number(s)

G02.111.570.080.689.450

G05.360.080.689.450

G05.360.340.024.380.249

Concept/Terms

Locus Control Region

Below are MeSH descriptors whose meaning is more general than "Locus Control Region".

Biological Sciences [G]
Chemical Phenomena [G02]
Biochemical Phenomena [G02.111]
Molecular Structure [G02.111.570]
Base Sequence [G02.111.570.080]
Regulatory Sequences, Nucleic Acid [G02.111.570.080.689]
Locus Control Region [G02.111.570.080.689.450]
Genetic Phenomena [G05]
Genetic Structures [G05.360]
Base Sequence [G05.360.080]
Regulatory Sequences, Nucleic Acid [G05.360.080.689]
Locus Control Region [G05.360.080.689.450]
Genome [G05.360.340]
Genome Components [G05.360.340.024]
Genetic Loci [G05.360.340.024.380]
Locus Control Region [G05.360.340.024.380.249]

Below are MeSH descriptors whose meaning is related to "Locus Control Region".

Below are MeSH descriptors whose meaning is more specific than "Locus Control Region".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Locus Control Region" by people in Harvard Catalyst Profiles by year, and whether "Locus Control Region" was a major or minor topic of these publication.

Below are the most recent publications written about "Locus Control Region" by people in Profiles.

Identification of a new genetic variant associated with cholecystitis: A multicenter genome-wide association study. J Trauma Acute Care Surg. 2020 07; 89(1):173-178.

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Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9. Genome Biol. 2020 03 05; 21(1):59.

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Comparative analysis of three-dimensional chromosomal architecture identifies a novel fetal hemoglobin regulatory element. Genes Dev. 2017 08 15; 31(16):1704-1713.

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CTCF-binding elements 1 and 2 in the Igh intergenic control region cooperatively regulate V(D)J recombination. Proc Natl Acad Sci U S A. 2015 Feb 10; 112(6):1815-20.

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ICR noncoding RNA expression controls imprinting and DNA replication at the Dlk1-Dio3 domain. Dev Cell. 2014 Oct 13; 31(1):19-33.

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A common atopy-associated variant in the Th2 cytokine locus control region impacts transcriptional regulation and alters SMAD3 and SP1 binding. Allergy. 2014 May; 69(5):632-42.

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Using ancient DNA to study the origins and dispersal of ancestral Polynesian chickens across the Pacific. Proc Natl Acad Sci U S A. 2014 Apr 01; 111(13):4826-31.

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Dissecting the function of the adult ß-globin downstream promoter region using an artificial zinc finger DNA-binding domain. Nucleic Acids Res. 2014 Apr; 42(7):4363-74.

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Keeping fetal hemoglobin in the loop. Cell Cycle. 2014; 13(20):3153-4.

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Fetal hemoglobin in sickle cell anemia: genetic studies of the Arab-Indian haplotype. Blood Cells Mol Dis. 2013 Jun; 51(1):22-6.

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