Leukemia, Large Granular Lymphocytic
"Leukemia, Large Granular Lymphocytic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A spectrum of disorders characterized by clonal expansions of the peripheral blood LYMPHOCYTE populations known as large granular lymphocytes which contain abundant cytoplasm and azurophilic granules. Subtypes develop from either CD3-negative NATURAL KILLER CELLS or CD3-positive T-CELLS. The clinical course of both subtypes can vary from spontaneous regression to progressive, malignant disease.
MeSH Number(s)
C04.557.337.428.580.049
C15.604.515.560.575.049
C20.683.515.528.582.049
Concept/Terms
Leukemia, Large Granular Lymphocytic- Leukemia, Large Granular Lymphocytic
- Leukemia, LGL
- LGL Leukemias
- Leukemias, LGL
- Lymphoproliferative Disease of Large Granular Lymphocytes
- LGL Leukemia
- Lymphoproliferative Disease of Granular Lymphocytes
- Large Granular Lymphocyte Leukemia
- Leukemia, Lymphocytic, Large Granular
Leukemia, T-Cell Large Granular Lymphocytic- Leukemia, T-Cell Large Granular Lymphocytic
- Leukemia, T Cell Large Granular Lymphocytic
- T-Cell Large Granular Lymphocyte Leukemia
- T Cell Large Granular Lymphocyte Leukemia
- T-LGL Leukemia
- T LGL Leukemia
- Leukemia, T-LGL
- Leukemia, T LGL
- Leukemias, T-LGL
- T-LGL Leukemias
- T-Cell Large Granular Lymphocytic Leukemia
- T Cell Large Granular Lymphocytic Leukemia
Leukemia, Natural Killer Cell Large Granular Lymphocytic- Leukemia, Natural Killer Cell Large Granular Lymphocytic
- NK-LGL Leukemia
- NK LGL Leukemia
- NK-Cell Large Granular Lymphocytic Leukemia
- NK Cell Large Granular Lymphocytic Leukemia
- Leukemia, NK-LGL
- Leukemia, NK LGL
- Leukemias, NK-LGL
- NK-LGL Leukemias
- Natural Killer Cell Large Granular Lymphocytic Leukemia
Below are MeSH descriptors whose meaning is more general than "Leukemia, Large Granular Lymphocytic".
Below are MeSH descriptors whose meaning is more specific than "Leukemia, Large Granular Lymphocytic".
This graph shows the total number of publications written about "Leukemia, Large Granular Lymphocytic" by people in Harvard Catalyst Profiles by year, and whether "Leukemia, Large Granular Lymphocytic" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2008 | 0 | 1 | 1 |
| 2009 | 0 | 1 | 1 |
| 2011 | 2 | 0 | 2 |
| 2012 | 3 | 0 | 3 |
| 2013 | 2 | 1 | 3 |
| 2014 | 1 | 1 | 2 |
| 2015 | 2 | 0 | 2 |
| 2016 | 2 | 0 | 2 |
| 2018 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "Leukemia, Large Granular Lymphocytic" by people in Profiles.
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Frequent somatic TET2 mutations in chronic NK-LGL leukemia with distinct patterns of cytopenias. Blood. 2021 08 26; 138(8):662-673.
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Inclusion-body myositis and primary Sjögren syndrome: mechanisms for shared etiologies. Muscle Nerve. 2020 05; 61(5):570-574.
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Aggressive natural killer-cell leukemia mutational landscape and drug profiling highlight JAK-STAT signaling as therapeutic target. Nat Commun. 2018 04 19; 9(1):1567.
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High incidence of activating STAT5B mutations in CD4-positive T-cell large granular lymphocyte leukemia. Blood. 2016 11 17; 128(20):2465-2468.
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Association of inclusion body myositis with T cell large granular lymphocytic leukaemia. Brain. 2016 05; 139(Pt 5):1348-60.
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Activating somatic mutations outside the SH2-domain of STAT3 in LGL leukemia. Leukemia. 2016 05; 30(5):1204-8.
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Allogeneic hematopoietic cell transplantation in a dog with acute large granular lymphocytic leukemia. J Am Vet Med Assoc. 2015 May 01; 246(9):994-7.
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Autoimmunity, hypogammaglobulinemia, lymphoproliferation, and mycobacterial disease in patients with activating mutations in STAT3. Blood. 2015 Jan 22; 125(4):639-48.
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De novo CD3 negative hepatosplenic T-cell lymphoma: diagnostic challenges and pitfalls. Arch Pathol Lab Med. 2014 Jul; 138(7):969-73.
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Prevalence of autoimmune hematologic and non-hematologic conditions in large granular lymphocytic leukemia: exploratory analysis of a series of consecutive patients. Leuk Lymphoma. 2014 Jun; 55(6):1399-401.