Harvard Catalyst Profiles

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Leucine Zippers

"Leucine Zippers" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

DNA-binding motifs formed from two alpha-helixes which intertwine for about eight turns into a coiled coil and then bifurcate to form Y shaped structures. Leucines occurring in heptad repeats end up on the same sides of the helixes and are adjacent to each other in the stem of the Y (the "zipper" region). The DNA-binding residues are located in the bifurcated region of the Y.

This graph shows the total number of publications written about "Leucine Zippers" by people in Harvard Catalyst Profiles by year, and whether "Leucine Zippers" was a major or minor topic of these publication.
Bar chart showing 74 publications over 21 distinct years, with a maximum of 10 publications in 1996
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.