"Kininogen, High-Molecular-Weight" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plasma protein, molecular weight of 110 kD, that normally exists in plasma in a 1:1 complex with PREKALLIKREIN. HMWK is split by plasma kallikrein to produce BRADYKININ. The complex is a cofactor in the activation of coagulation factor XII. The product of this reaction, XIIa, in turn activates prekallikrein to KALLIKREINS. (From Stedman, 26th ed)
- Kininogen, High-Molecular-Weight
- Kininogen, High Molecular Weight
- High Molecular Weight Kininogens
- Kininogens, High Molecular Weight
- High-Molecular-Weight Kininogens
- Kininogens, High-Molecular-Weight
- High-Molecular-Weight Kininogen
- Fitzgerald Factor
- High Molecular Weight Kininogen
Below are MeSH descriptors whose meaning is more general than "Kininogen, High-Molecular-Weight".
Below are MeSH descriptors whose meaning is more specific than "Kininogen, High-Molecular-Weight".
This graph shows the total number of publications written about "Kininogen, High-Molecular-Weight" by people in Harvard Catalyst Profiles by year, and whether "Kininogen, High-Molecular-Weight" was a major or minor topic of these publication.
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|Year||Major Topic||Minor Topic||Total|
Below are the most recent publications written about "Kininogen, High-Molecular-Weight" by people in Profiles.
An antibody against HK blocks Alzheimer's disease peptide ß-amyloid-induced bradykinin release in human plasma. Proc Natl Acad Sci U S A. 2019 11 12; 116(46):22921-22923.
The high-molecular-weight kininogen domain 5 is an intrinsically unstructured protein and its interaction with ferritin is metal mediated. Protein Sci. 2014 Aug; 23(8):1013-22.
Plasma kininogen and kininogen fragments are biomarkers of progressive renal decline in type 1 diabetes. Kidney Int. 2013 Jun; 83(6):1177-84.
Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells. PLoS One. 2012; 7(7):e40030.
High molecular weight kininogen activates B2 receptor signaling pathway in human vascular endothelial cells. J Biol Chem. 2011 Jul 15; 286(28):24561-71.
Biochemical characterization of a novel high-affinity and specific plasma kallikrein inhibitor. Br J Pharmacol. 2011 Apr; 162(7):1639-49.
Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ. Hum Mol Genet. 2010 Dec 15; 19(24):4955-64.
Identification of coagulation factor XI as a ligand for platelet apolipoprotein E receptor 2 (ApoER2). Arterioscler Thromb Vasc Biol. 2009 Oct; 29(10):1602-7.
Identification of lipopolysaccharide binding site on high molecular weight kininogen. Biochem Biophys Res Commun. 2008 Feb 22; 366(4):938-43.
Myeloperoxidase interacts with endothelial cell-surface cytokeratin 1 and modulates bradykinin production by the plasma Kallikrein-Kinin system. Am J Pathol. 2007 Jul; 171(1):349-60.