Harvard Catalyst Profiles

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Integrin alphaVbeta3

"Integrin alphaVbeta3" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).


This graph shows the total number of publications written about "Integrin alphaVbeta3" by people in Harvard Catalyst Profiles by year, and whether "Integrin alphaVbeta3" was a major or minor topic of these publication.
Bar chart showing 68 publications over 17 distinct years, with a maximum of 10 publications in 2012
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.