"Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
MeSH Number(s)
D06.472.699.587.200.500.625
D12.644.548.586.200.500.625
Concept/Terms
Insulin- Insulin
- Insulin, Regular
- Regular Insulin
- Soluble Insulin
- Insulin, Soluble
Below are MeSH descriptors whose meaning is more general than "Insulin".
Below are MeSH descriptors whose meaning is more specific than "Insulin".
This graph shows the total number of publications written about "Insulin" by people in Harvard Catalyst Profiles by year, and whether "Insulin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 28 | 33 | 61 |
| 1993 | 38 | 36 | 74 |
| 1994 | 32 | 34 | 66 |
| 1995 | 29 | 34 | 63 |
| 1996 | 41 | 23 | 64 |
| 1997 | 39 | 40 | 79 |
| 1998 | 25 | 43 | 68 |
| 1999 | 52 | 40 | 92 |
| 2000 | 40 | 61 | 101 |
| 2001 | 50 | 55 | 105 |
| 2002 | 55 | 65 | 120 |
| 2003 | 51 | 73 | 124 |
| 2004 | 50 | 79 | 129 |
| 2005 | 48 | 62 | 110 |
| 2006 | 56 | 74 | 130 |
| 2007 | 52 | 92 | 144 |
| 2008 | 62 | 103 | 165 |
| 2009 | 59 | 93 | 152 |
| 2010 | 72 | 78 | 150 |
| 2011 | 59 | 89 | 148 |
| 2012 | 83 | 88 | 171 |
| 2013 | 69 | 83 | 152 |
| 2014 | 71 | 94 | 165 |
| 2015 | 67 | 85 | 152 |
| 2016 | 75 | 82 | 157 |
| 2017 | 60 | 78 | 138 |
| 2018 | 47 | 61 | 108 |
| 2019 | 61 | 84 | 145 |
| 2020 | 38 | 56 | 94 |
| 2021 | 38 | 56 | 94 |
| 2022 | 2 | 7 | 9 |
Below are the most recent publications written about "Insulin" by people in Profiles.
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Interplay of Dinner Timing and MTNR1B Type 2 Diabetes Risk Variant on Glucose Tolerance and Insulin Secretion: A Randomized Crossover Trial. Diabetes Care. 2022 03 01; 45(3):512-519.
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A salivary gland-secreted peptide regulates insect systemic growth. Cell Rep. 2022 02 22; 38(8):110397.
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Gain of Function of Malate Dehydrogenase 2 and Familial Hyperglycemia. J Clin Endocrinol Metab. 2022 02 17; 107(3):668-684.
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Separating the direct effects of traits on atherosclerotic cardiovascular disease from those mediated by type 2 diabetes. Diabetologia. 2022 May; 65(5):790-799.
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Blood-derived miRNA levels are not correlated with metabolic or anthropometric parameters in obese pre-diabetic subjects but with systemic inflammation. PLoS One. 2022; 17(2):e0263479.
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A d-cell subpopulation with a pro-ß-cell identity contributes to efficient age-independent recovery in a zebrafish model of diabetes. Elife. 2022 01 21; 11.
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Effects of a low-carbohydrate diet on insulin-resistant dyslipoproteinemia-a randomized controlled feeding trial. Am J Clin Nutr. 2022 01 11; 115(1):154-162.
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Insulin regulates arginine-stimulated insulin secretion in humans. Metabolism. 2022 03; 128:155117.
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Use of Technology in Older Adults with Type 1 Diabetes: Clinical Characteristics and Glycemic Metrics. Diabetes Technol Ther. 2022 01; 24(1):1-9.
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Insulin signalling in tanycytes gates hypothalamic insulin uptake and regulation of AgRP neuron activity. Nat Metab. 2021 12; 3(12):1662-1679.