"Insulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).
MeSH Number(s)
D06.472.699.587.200.500.625
D12.644.548.586.200.500.625
Concept/Terms
Insulin- Insulin
- Insulin, Regular
- Regular Insulin
- Soluble Insulin
- Insulin, Soluble
Below are MeSH descriptors whose meaning is more general than "Insulin".
Below are MeSH descriptors whose meaning is more specific than "Insulin".
This graph shows the total number of publications written about "Insulin" by people in Harvard Catalyst Profiles by year, and whether "Insulin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 38 | 34 | 72 |
| 1994 | 32 | 34 | 66 |
| 1995 | 29 | 34 | 63 |
| 1996 | 41 | 22 | 63 |
| 1997 | 39 | 40 | 79 |
| 1998 | 25 | 43 | 68 |
| 1999 | 52 | 40 | 92 |
| 2000 | 39 | 61 | 100 |
| 2001 | 49 | 56 | 105 |
| 2002 | 55 | 65 | 120 |
| 2003 | 54 | 75 | 129 |
| 2004 | 49 | 79 | 128 |
| 2005 | 47 | 61 | 108 |
| 2006 | 57 | 74 | 131 |
| 2007 | 51 | 94 | 145 |
| 2008 | 60 | 100 | 160 |
| 2009 | 58 | 95 | 153 |
| 2010 | 73 | 81 | 154 |
| 2011 | 59 | 87 | 146 |
| 2012 | 87 | 82 | 169 |
| 2013 | 69 | 79 | 148 |
| 2014 | 72 | 90 | 162 |
| 2015 | 62 | 81 | 143 |
| 2016 | 76 | 84 | 160 |
| 2017 | 58 | 76 | 134 |
| 2018 | 48 | 61 | 109 |
| 2019 | 63 | 84 | 147 |
| 2020 | 38 | 59 | 97 |
| 2021 | 40 | 71 | 111 |
| 2022 | 16 | 96 | 112 |
| 2023 | 3 | 11 | 14 |
Below are the most recent publications written about "Insulin" by people in Profiles.
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Lower Hepatic Fat Is Associated With Improved Insulin Secretion in a High-Risk Prediabetes Subphenotype During Lifestyle Intervention. Diabetes. 2023 Mar 01; 72(3):362-366.
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Associations between oral processing, saliva, and bolus properties on daily glucose excursions amongst people at risk of type-2 diabetes. Food Funct. 2023 Feb 21; 14(4):2260-2269.
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Leucine-973 is a crucial residue differentiating insulin and IGF-1 receptor signaling. J Clin Invest. 2023 Feb 15; 133(4).
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Management of Individuals With Diabetes at High Risk for Hypoglycemia: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab. 2023 Feb 15; 108(3):529-562.
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SerpinA3N deficiency attenuates steatosis and enhances insulin signaling in male mice. J Endocrinol. 2023 Mar 01; 256(3).
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Insulin products and patents in the USA in 2004, 2014, and 2020: a cross-sectional study. Lancet Diabetes Endocrinol. 2023 02; 11(2):73-75.
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Implementation of self-monitoring of blood glucose for patients with insulin-dependent diabetes at a rural non-communicable disease clinic in Neno, Malawi. S Afr Med J. 2023 Feb 01; 113(2):84-90.
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Loci for insulin processing and secretion provide insight into type 2 diabetes risk. Am J Hum Genet. 2023 02 02; 110(2):284-299.
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Islet Inflammation Can Be Linked to the Disruption of Proinsulin Processing in Type 1 Diabetes but not in Type 2 Diabetes. J Clin Endocrinol Metab. 2023 01 17; 108(2):e21-e22.
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Impact of sex and diet-induced weight loss on vascular insulin sensitivity in type 2 diabetes. Am J Physiol Regul Integr Comp Physiol. 2023 03 01; 324(3):R293-R304.