Harvard Catalyst Profiles

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Immunoglobulin Class Switching

"Immunoglobulin Class Switching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Gene rearrangement of the B-lymphocyte which results in a substitution in the type of heavy-chain constant region that is expressed. This allows the effector response to change while the antigen binding specificity (variable region) remains the same. The majority of class switching occurs by a DNA recombination event but it also can take place at the level of RNA processing.


This graph shows the total number of publications written about "Immunoglobulin Class Switching" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin Class Switching" was a major or minor topic of these publication.
Bar chart showing 176 publications over 28 distinct years, with a maximum of 11 publications in 2008
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.