Imipramine

"Imipramine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.

Descriptor ID

D007099

MeSH Number(s)

D03.494.240.485

Concept/Terms

Imipramine Hydrochloride

Janimine

Below are MeSH descriptors whose meaning is more general than "Imipramine".

Chemicals and Drugs [D]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 3-Ring [D03.494]
Dibenzazepines [D03.494.240]
Imipramine [D03.494.240.485]

Below are MeSH descriptors whose meaning is related to "Imipramine".

Below are MeSH descriptors whose meaning is more specific than "Imipramine".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Imipramine" by people in Harvard Catalyst Profiles by year, and whether "Imipramine" was a major or minor topic of these publication.

Bar chart showing 44 publications over 18 distinct years, with a maximum of 5 publications in 1996

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1993	4	0	4
1994	1	3	4
1995	0	4	4
1996	3	2	5
1997	2	0	2
2000	1	1	2
2001	2	0	2
2002	2	0	2
2005	0	2	2
2006	2	2	4
2007	1	1	2
2008	1	1	2
2009	2	0	2
2010	0	1	1
2012	1	1	2
2014	1	0	1
2015	0	1	1
2017	0	2	2

Below are the most recent publications written about "Imipramine" by people in Profiles.

Direct comparison of tricyclic and serotonin-reuptake inhibitor antidepressants in randomized head-to-head trials in acute major depression: Systematic review and meta-analysis. J Psychopharmacol. 2017 09; 31(9):1184-1189.

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A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats. Physiol Behav. 2017 Sep 01; 178:82-92.

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Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia. Oncotarget. 2016 08 09; 7(32):51651-51664.

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Role of acid sphingomyelinase bioactivity in human CD4+ T-cell activation and immune responses. Cell Death Dis. 2015 Jul 23; 6:e1828.

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Chronic administration of anticonvulsants but not antidepressants impairs bone strength: clinical implications. Transl Psychiatry. 2015 Jun 02; 5:e576.

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Acute and Chronic Treatments with Quetiapine Increase Mitochondrial Respiratory Chain Complex Activity in the Rat Brain. Curr Neurovasc Res. 2015; 12(3):283-92.

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Effects of antidepressant drug exposure on gene expression in the developing cerebral cortex. Synapse. 2014 May; 68(5):209-20.

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Impact of antidepressant therapy on cognitive aspects of work, condom use, and psychosocial well-being among HIV clients in Uganda. Int J Psychiatry Med. 2014; 48(3):155-66.

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Re-analysis of the earliest controlled trials of imipramine. J Affect Disord. 2013 May; 147(1-3):451-4.

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HDAC6 regulates glucocorticoid receptor signaling in serotonin pathways with critical impact on stress resilience. J Neurosci. 2012 Mar 28; 32(13):4400-16.

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