Hyperkeratosis, Epidermolytic
"Hyperkeratosis, Epidermolytic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A form of congenital ichthyosis inherited as an autosomal dominant trait and characterized by ERYTHRODERMA and severe hyperkeratosis. It is manifested at birth by blisters followed by the appearance of thickened, horny, verruciform scales over the entire body, but accentuated in flexural areas. Mutations in the genes that encode KERATIN-1 and KERATIN-10 have been associated with this disorder.
MeSH Number(s)
C16.131.831.512.400.375
C16.320.850.400.375
C16.614.492.400.375
C17.800.428.333.250.375
C17.800.804.512.400.375
C17.800.827.400.375
Concept/Terms
Hyperkeratosis, Epidermolytic- Hyperkeratosis, Epidermolytic
- Epidermolytic Hyperkeratoses
- Epidermolytic Hyperkeratosis
- Hyperkeratoses, Epidermolytic
- Bullous Ichthyosiform Erythroderma Congenital
- Congenital Bullous Ichthyosiform Erythroderma
- Bullous Ichthyosiform Erythroderma
- Bullous Ichthyosiform Erythrodermas
- Erythroderma, Bullous Ichthyosiform
- Erythrodermas, Bullous Ichthyosiform
- Ichthyosiform Erythroderma, Bullous
- Ichthyosiform Erythrodermas, Bullous
- Erythroderma Ichthyosiforme, Bullous
- Bullous Erythroderma Ichthyosiforme
- Bullous Erythroderma Ichthyosiformes
- Erythroderma Ichthyosiformes, Bullous
- Ichthyosiforme, Bullous Erythroderma
- Ichthyosiformes, Bullous Erythroderma
- Ichthyosiform Erythroderma, Bullous Congenital
- Bullous Erythroderma Ichthyosiformis Congenita of Brocq
- Bullous Congenital Ichthyosiform Erythroderma
- Congenital Ichthyosiform Erythroderma, Bullous
Below are MeSH descriptors whose meaning is more general than "Hyperkeratosis, Epidermolytic".
- Diseases [C]
- Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
- Congenital Abnormalities [C16.131]
- Skin Abnormalities [C16.131.831]
- Ichthyosis [C16.131.831.512]
- Ichthyosiform Erythroderma, Congenital [C16.131.831.512.400]
- Hyperkeratosis, Epidermolytic [C16.131.831.512.400.375]
- Genetic Diseases, Inborn [C16.320]
- Skin Diseases, Genetic [C16.320.850]
- Ichthyosiform Erythroderma, Congenital [C16.320.850.400]
- Hyperkeratosis, Epidermolytic [C16.320.850.400.375]
- Infant, Newborn, Diseases [C16.614]
- Ichthyosis [C16.614.492]
- Ichthyosiform Erythroderma, Congenital [C16.614.492.400]
- Hyperkeratosis, Epidermolytic [C16.614.492.400.375]
- Skin and Connective Tissue Diseases [C17]
- Skin Diseases [C17.800]
- Keratosis [C17.800.428]
- Ichthyosis [C17.800.428.333]
- Ichthyosiform Erythroderma, Congenital [C17.800.428.333.250]
- Hyperkeratosis, Epidermolytic [C17.800.428.333.250.375]
- Skin Abnormalities [C17.800.804]
- Ichthyosis [C17.800.804.512]
- Ichthyosiform Erythroderma, Congenital [C17.800.804.512.400]
- Hyperkeratosis, Epidermolytic [C17.800.804.512.400.375]
- Skin Diseases, Genetic [C17.800.827]
- Ichthyosiform Erythroderma, Congenital [C17.800.827.400]
- Hyperkeratosis, Epidermolytic [C17.800.827.400.375]
Below are MeSH descriptors whose meaning is more specific than "Hyperkeratosis, Epidermolytic".
This graph shows the total number of publications written about "Hyperkeratosis, Epidermolytic" by people in Harvard Catalyst Profiles by year, and whether "Hyperkeratosis, Epidermolytic" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 1 | 0 | 1 |
| 1996 | 2 | 0 | 2 |
| 1997 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2017 | 1 | 0 | 1 |
Below are the most recent publications written about "Hyperkeratosis, Epidermolytic" by people in Profiles.
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Epidermolytic Ichthyosis Sine Epidermolysis. Am J Dermatopathol. 2017 Jun; 39(6):440-444.
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KRIT1 is mutated in hyperkeratotic cutaneous capillary-venous malformation associated with cerebral capillary malformation. Hum Mol Genet. 2000 May 22; 9(9):1351-5.
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Cyclic ichthyosis with epidermolytic hyperkeratosis: A phenotype conferred by mutations in the 2B domain of keratin K1. Am J Hum Genet. 1999 Mar; 64(3):732-8.
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Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Invest New Drugs. 1999; 17(2):121-35.
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A novel nonepidermolytic palmoplantar keratoderma: a clinical and histopathologic study of six cases. J Am Acad Dermatol. 1997 Jul; 37(1):27-33.
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Epidermolytic hyperkeratosis. Int J Dermatol. 1996 Aug; 35(8):579-81.
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Gene targeting at the mouse cytokeratin 10 locus: severe skin fragility and changes of cytokeratin expression in the epidermis. J Cell Biol. 1996 Mar; 132(5):925-36.
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Genetic bases of epidermolysis bullosa simplex and epidermolytic hyperkeratosis. J Invest Dermatol. 1994 Nov; 103(5 Suppl):25S-30S.