Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Hirudins

"Hirudins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Single-chain polypeptides of about 65 amino acids (7 kDa) from LEECHES that have a neutral hydrophobic N terminus, an acidic hydrophilic C terminus, and a compact, hydrophobic core region. Recombinant hirudins lack tyr-63 sulfation and are referred to as 'desulfato-hirudins'. They form a stable non-covalent complex with ALPHA-THROMBIN, thereby abolishing its ability to cleave FIBRINOGEN.


This graph shows the total number of publications written about "Hirudins" by people in Harvard Catalyst Profiles by year, and whether "Hirudins" was a major or minor topic of these publication.
Bar chart showing 123 publications over 29 distinct years, with a maximum of 11 publications in 2015
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.