Hemoglobinuria, Paroxysmal
"Hemoglobinuria, Paroxysmal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A condition characterized by the recurrence of HEMOGLOBINURIA caused by intravascular HEMOLYSIS. In cases occurring upon cold exposure (paroxysmal cold hemoglobinuria), usually after infections, there is a circulating antibody which is also a cold hemolysin. In cases occurring during or after sleep (paroxysmal nocturnal hemoglobinuria), the clonal hematopoietic stem cells exhibit a global deficiency of cell membrane proteins.
MeSH Number(s)
C15.378.071.141.560
C15.378.190.625.460
Concept/Terms
Paroxysmal Cold Hemoglobinuria- Paroxysmal Cold Hemoglobinuria
- Hemoglobinuria, Paroxysmal Cold
- Paroxysmal Hemoglobinuria, Cold
- Cold Paroxysmal Hemoglobinuria
- Hemoglobinuria, Cold Paroxysmal
Paroxysmal Nocturnal Hemoglobinuria- Paroxysmal Nocturnal Hemoglobinuria
- Hemoglobinuria, Paroxysmal Nocturnal
- Marchiafava-Micheli Syndrome
- Marchiafava Micheli Syndrome
- Syndrome, Marchiafava-Micheli
- Paroxysmal Hemoglobinuria, Nocturnal
- Hemoglobinuria, Nocturnal Paroxysmal
- Nocturnal Paroxysmal Hemoglobinuria
Below are MeSH descriptors whose meaning is more general than "Hemoglobinuria, Paroxysmal".
Below are MeSH descriptors whose meaning is more specific than "Hemoglobinuria, Paroxysmal".
This graph shows the total number of publications written about "Hemoglobinuria, Paroxysmal" by people in Harvard Catalyst Profiles by year, and whether "Hemoglobinuria, Paroxysmal" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 1 | 1 |
| 1999 | 1 | 0 | 1 |
| 2001 | 0 | 1 | 1 |
| 2003 | 1 | 1 | 2 |
| 2007 | 1 | 0 | 1 |
| 2008 | 4 | 1 | 5 |
| 2009 | 1 | 0 | 1 |
| 2010 | 0 | 2 | 2 |
| 2011 | 3 | 1 | 4 |
| 2012 | 1 | 0 | 1 |
| 2013 | 3 | 0 | 3 |
| 2014 | 4 | 0 | 4 |
| 2015 | 3 | 0 | 3 |
| 2016 | 2 | 1 | 3 |
| 2017 | 4 | 0 | 4 |
| 2018 | 4 | 0 | 4 |
| 2019 | 2 | 0 | 2 |
| 2020 | 1 | 0 | 1 |
| 2021 | 4 | 0 | 4 |
| 2022 | 1 | 0 | 1 |
Below are the most recent publications written about "Hemoglobinuria, Paroxysmal" by people in Profiles.
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Literature Review of Fatigue Scales and Association with Clinically Meaningful Improvements in Outcomes Among Patients With and Without Paroxysmal Nocturnal Hemoglobinuria. Adv Ther. 2022 05; 39(5):1959-1975.
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Comparative effectiveness of pegcetacoplan versus ravulizumab in patients with paroxysmal nocturnal hemoglobinuria previously treated with eculizumab: a matching-adjusted indirect comparison. Curr Med Res Opin. 2021 11; 37(11):1913-1923.
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Real-World Healthcare Resource Utilization (HRU) and Costs of Patients with Paroxysmal Nocturnal Hemoglobinuria (PNH) Receiving Eculizumab in a US Population. Adv Ther. 2021 08; 38(8):4461-4479.
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Iron overload after complement inhibitor treatment of Paroxysmal Nocturnal Hemoglobinuria. Am J Hematol. 2021 07 01; 96(7):E235-E237.
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Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria. Clin Pharmacokinet. 2021 03; 60(3):365-378.
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Paroxysmal Nocturnal Hemoglobinuria Presenting with Hemorrhagic Esophageal Varices. Am J Med. 2021 03; 134(3):e147-e149.
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Neutrophils develop rapid proinflammatory response after engulfing Hb-activated platelets under intravascular hemolysis. Clin Exp Immunol. 2019 Aug; 197(2):131-140.
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Ravulizumab: a complementary option for PNH. Blood. 2019 02 07; 133(6):503-504.
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Introduction to Acquired and Inherited Bone Marrow Failure. Hematol Oncol Clin North Am. 2018 08; 32(4):569-580.
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Acquired and Inherited Bone Marrow Failure Syndromes. Hematol Oncol Clin North Am. 2018 08; 32(4):xiii-xiv.