Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Heavy Chain Disease

"Heavy Chain Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A disorder of immunoglobulin synthesis in which large quantities of abnormal heavy chains are excreted in the urine. The amino acid sequences of the N-(amino-) terminal regions of these chains are normal, but they have a deletion extending from part of the variable domain through the first domain of the constant region, so that they cannot form cross-links to the light chains. The defect arises through faulty coupling of the variable (V) and constant (C) region genes.


This graph shows the total number of publications written about "Heavy Chain Disease" by people in Harvard Catalyst Profiles by year, and whether "Heavy Chain Disease" was a major or minor topic of these publication.
Bar chart showing 9 publications over 6 distinct years, with a maximum of 4 publications in 2014
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.