"Half-Life" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.
Concept/Terms
Half-Life- Half-Life
- Half Life
- Half-Lifes
- Halflife
- Halflifes
Below are MeSH descriptors whose meaning is more general than "Half-Life".
Below are MeSH descriptors whose meaning is more specific than "Half-Life".
This graph shows the total number of publications written about "Half-Life" by people in Harvard Catalyst Profiles by year, and whether "Half-Life" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 0 | 9 | 9 |
| 1994 | 0 | 5 | 5 |
| 1995 | 0 | 13 | 13 |
| 1996 | 0 | 9 | 9 |
| 1997 | 0 | 10 | 10 |
| 1998 | 0 | 9 | 9 |
| 1999 | 0 | 13 | 13 |
| 2000 | 0 | 15 | 15 |
| 2001 | 0 | 16 | 16 |
| 2002 | 0 | 12 | 12 |
| 2003 | 0 | 14 | 14 |
| 2004 | 0 | 23 | 23 |
| 2005 | 0 | 12 | 12 |
| 2006 | 0 | 11 | 11 |
| 2007 | 0 | 13 | 13 |
| 2008 | 0 | 13 | 13 |
| 2009 | 0 | 15 | 15 |
| 2010 | 0 | 7 | 7 |
| 2011 | 0 | 10 | 10 |
| 2012 | 0 | 27 | 27 |
| 2013 | 0 | 7 | 7 |
| 2014 | 0 | 14 | 14 |
| 2015 | 0 | 14 | 14 |
| 2016 | 0 | 11 | 11 |
| 2017 | 0 | 18 | 18 |
| 2018 | 0 | 14 | 14 |
| 2019 | 0 | 12 | 12 |
| 2020 | 1 | 10 | 11 |
| 2021 | 0 | 5 | 5 |
| 2022 | 0 | 4 | 4 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Half-Life" by people in Profiles.
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Variant-Specific Viral Kinetics in Acute COVID-19. J Infect Dis. 2023 08 31; 228(Suppl 2):S136-S143.
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Sialylation of IgE reduces FceRIa interaction and mast cell and basophil activation in vitro and increases IgE half-life in vivo. Allergy. 2023 08; 78(8):2301-2305.
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Precision of the PET activity range during irradiation with10C,11C, and12C beams. Phys Med Biol. 2022 12 19; 68(1).
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Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life. Sci Rep. 2022 Oct 25; 12(1):17876.
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Deep mutational scanning and massively parallel kinetics of plasminogen activator inhibitor-1 functional stability to probe its latency transition. J Biol Chem. 2022 12; 298(12):102608.
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Predicting pesticide dissipation half-life intervals in plants with machine learning models. J Hazard Mater. 2022 08 15; 436:129177.
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A pilot-randomized, double-blind crossover trial to evaluate the pharmacokinetics of orally administered 25-hydroxyvitamin D3 and vitamin D3 in healthy adults with differing BMI and in adults with intestinal malabsorption. Am J Clin Nutr. 2021 09 01; 114(3):1189-1199.
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A multicenter phase 1/2 study investigating the safety, pharmacokinetics, pharmacodynamics and efficacy of a small molecule antimetabolite, RX-3117, plus nab-paclitaxel in pancreatic adenocarcinoma. Invest New Drugs. 2022 02; 40(1):81-90.
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Targeting p130Cas- and microtubule-dependent MYC regulation sensitizes pancreatic cancer to ERK MAPK inhibition. Cell Rep. 2021 06 29; 35(13):109291.
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Highly Efficient Activatable MRI Probe to Sense Myeloperoxidase Activity. J Med Chem. 2021 05 13; 64(9):5874-5885.