Guanidinoacetate N-Methyltransferase

"Guanidinoacetate N-Methyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

This enzyme catalyzes the last step of CREATINE biosynthesis by catalyzing the METHYLATION of guanidinoacetate to CREATINE.

Descriptor ID

D050937

MeSH Number(s)

D08.811.913.555.500.425

Concept/Terms

Guanidinoacetate N-Methyltransferase

Below are MeSH descriptors whose meaning is more general than "Guanidinoacetate N-Methyltransferase".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Transferases [D08.811.913]
One-Carbon Group Transferases [D08.811.913.555]
Methyltransferases [D08.811.913.555.500]
Guanidinoacetate N-Methyltransferase [D08.811.913.555.500.425]

Below are MeSH descriptors whose meaning is related to "Guanidinoacetate N-Methyltransferase".

Below are MeSH descriptors whose meaning is more specific than "Guanidinoacetate N-Methyltransferase".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Guanidinoacetate N-Methyltransferase" by people in Harvard Catalyst Profiles by year, and whether "Guanidinoacetate N-Methyltransferase" was a major or minor topic of these publication.

Below are the most recent publications written about "Guanidinoacetate N-Methyltransferase" by people in Profiles.

Biochemical and behavioral phenotype of AGAT and GAMT deficient mice following long-term Creatine monohydrate supplementation. Metab Brain Dis. 2017 Dec; 32(6):1951-1961.

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Laboratory diagnosis of creatine deficiency syndromes: a technical standard and guideline of the American College of Medical Genetics and Genomics. Genet Med. 2017 02; 19(2):256-263.

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Prolonged feeding with guanidinoacetate, a methyl group consumer, exacerbates ethanol-induced liver injury. World J Gastroenterol. 2016 Oct 14; 22(38):8497-8508.

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Atorvastatin increases miR-124a expression: a mechanism of Gamt modulation in liver cells. J Cell Biochem. 2015 Nov; 116(11):2620-7.

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Early alterations of brain cellular energy homeostasis in Huntington disease models. J Biol Chem. 2012 Jan 06; 287(2):1361-70.

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Molecular analysis of guanidinoacetate-n-methyltransferase (GAMT) and creatine transporter (SLC6A8) gene by using denaturing high pressure liquid chromatography (DHPLC) as a possible source of human male infertility. Pak J Pharm Sci. 2011 Jan; 24(1):75-9.

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GAMT joins the p53 network: branching into metabolism. Cell Cycle. 2010 May; 9(9):1706-10.

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GAMT, a p53-inducible modulator of apoptosis, is critical for the adaptive response to nutrient stress. Mol Cell. 2009 Nov 13; 36(3):379-92.

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Guanidinoacetate methyltransferase (GAMT) deficiency: late onset of movement disorder and preserved expressive language. Dev Med Child Neurol. 2009 May; 51(5):404-7.

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Low creatinine: the diagnostic clue for a treatable neurologic disorder. Neurology. 2009 Mar 03; 72(9):854-5.

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Pak J Pharm Sci
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