Harvard Catalyst Profiles

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Giant Cells

"Giant Cells" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.

This graph shows the total number of publications written about "Giant Cells" by people in Harvard Catalyst Profiles by year, and whether "Giant Cells" was a major or minor topic of these publication.
Bar chart showing 119 publications over 29 distinct years, with a maximum of 10 publications in 1996 and 2001
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.