"Genetic Heterogeneity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
Concept/Terms
Genetic Heterogeneity- Genetic Heterogeneity
- Heterogeneity, Genetic
- Genetic Heterogeneities
- Heterogeneities, Genetic
Below are MeSH descriptors whose meaning is more general than "Genetic Heterogeneity".
Below are MeSH descriptors whose meaning is more specific than "Genetic Heterogeneity".
This graph shows the total number of publications written about "Genetic Heterogeneity" by people in Harvard Catalyst Profiles by year, and whether "Genetic Heterogeneity" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 5 | 2 | 7 |
| 1996 | 2 | 3 | 5 |
| 1997 | 2 | 8 | 10 |
| 1998 | 4 | 4 | 8 |
| 1999 | 2 | 2 | 4 |
| 2000 | 4 | 6 | 10 |
| 2001 | 4 | 12 | 16 |
| 2002 | 3 | 5 | 8 |
| 2003 | 1 | 5 | 6 |
| 2004 | 2 | 6 | 8 |
| 2005 | 3 | 3 | 6 |
| 2006 | 0 | 7 | 7 |
| 2007 | 5 | 4 | 9 |
| 2008 | 3 | 5 | 8 |
| 2009 | 4 | 7 | 11 |
| 2010 | 5 | 5 | 10 |
| 2011 | 4 | 10 | 14 |
| 2012 | 8 | 8 | 16 |
| 2013 | 9 | 8 | 17 |
| 2014 | 11 | 21 | 32 |
| 2015 | 8 | 16 | 24 |
| 2016 | 8 | 17 | 25 |
| 2017 | 12 | 9 | 21 |
| 2018 | 6 | 10 | 16 |
| 2019 | 5 | 13 | 18 |
| 2020 | 11 | 13 | 24 |
| 2021 | 8 | 14 | 22 |
| 2022 | 2 | 2 | 4 |
Below are the most recent publications written about "Genetic Heterogeneity" by people in Profiles.
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Genetic Heterogeneity Shapes Brain Connectivity in Psychiatry. Biol Psychiatry. 2023 Jan 01; 93(1):45-58.
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ENPP1 variants in patients with GACI and PXE expand the clinical and genetic heterogeneity of heritable disorders of ectopic calcification. PLoS Genet. 2022 04; 18(4):e1010192.
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Deciphering spatial genomic heterogeneity at a single cell resolution in multiple myeloma. Nat Commun. 2022 02 10; 13(1):807.
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Single-cell analysis of human primary prostate cancer reveals the heterogeneity of tumor-associated epithelial cell states. Nat Commun. 2022 01 10; 13(1):141.
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Differential pre-malignant programs and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell. 2021 12 22; 184(26):6262-6280.e26.
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Clonal populations of a human TNBC model display significant functional heterogeneity and divergent growth dynamics in distinct contexts. Oncogene. 2022 01; 41(1):112-124.
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Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer. Nat Commun. 2021 09 21; 12(1):5563.
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Environmental Influences Measured by Epigenetic Clock and Vulnerability Components at Birth Impact Clinical ASD Heterogeneity. Genes (Basel). 2021 09 17; 12(9).
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Genetic Heterogeneity and Core Clinical Features of NOG-Related-Symphalangism Spectrum Disorder. Otol Neurotol. 2021 09 01; 42(8):e1143-e1151.
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Next-generation sequencing of cancer genomes: lessons learned. Future Oncol. 2021 11; 17(31):4041-4044.