"Genetic Heterogeneity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
Concept/Terms
Genetic Heterogeneity- Genetic Heterogeneity
- Heterogeneity, Genetic
- Genetic Heterogeneities
- Heterogeneities, Genetic
Below are MeSH descriptors whose meaning is more general than "Genetic Heterogeneity".
Below are MeSH descriptors whose meaning is more specific than "Genetic Heterogeneity".
This graph shows the total number of publications written about "Genetic Heterogeneity" by people in Harvard Catalyst Profiles by year, and whether "Genetic Heterogeneity" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 5 | 2 | 7 |
| 1996 | 2 | 3 | 5 |
| 1997 | 2 | 8 | 10 |
| 1998 | 4 | 4 | 8 |
| 1999 | 2 | 2 | 4 |
| 2000 | 4 | 6 | 10 |
| 2001 | 4 | 13 | 17 |
| 2002 | 3 | 7 | 10 |
| 2003 | 1 | 5 | 6 |
| 2004 | 2 | 6 | 8 |
| 2005 | 3 | 3 | 6 |
| 2006 | 1 | 7 | 8 |
| 2007 | 5 | 5 | 10 |
| 2008 | 3 | 5 | 8 |
| 2009 | 4 | 6 | 10 |
| 2010 | 5 | 5 | 10 |
| 2011 | 5 | 10 | 15 |
| 2012 | 7 | 8 | 15 |
| 2013 | 9 | 9 | 18 |
| 2014 | 11 | 20 | 31 |
| 2015 | 8 | 18 | 26 |
| 2016 | 7 | 17 | 24 |
| 2017 | 12 | 10 | 22 |
| 2018 | 7 | 11 | 18 |
| 2019 | 5 | 13 | 18 |
| 2020 | 9 | 11 | 20 |
| 2021 | 3 | 5 | 8 |
Below are the most recent publications written about "Genetic Heterogeneity" by people in Profiles.
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Molecular correlates of response to eribulin and pembrolizumab in hormone receptor-positive metastatic breast cancer. Nat Commun. 2021 09 21; 12(1):5563.
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Genetic Heterogeneity and Core Clinical Features of NOG-Related-Symphalangism Spectrum Disorder. Otol Neurotol. 2021 09 01; 42(8):e1143-e1151.
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Placental DNA methylation signatures of maternal smoking during pregnancy and potential impacts on fetal growth. Nat Commun. 2021 08 24; 12(1):5095.
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Deciphering transcriptional and functional heterogeneity in hematopoiesis with single-cell genomics. Curr Opin Hematol. 2021 07 01; 28(4):269-276.
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Cell-free DNA captures tumor heterogeneity and driver alterations in rapid autopsies with pre-treated metastatic cancer. Nat Commun. 2021 05 27; 12(1):3199.
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Single cell transcriptional and chromatin accessibility profiling redefine cellular heterogeneity in the adult human kidney. Nat Commun. 2021 04 13; 12(1):2190.
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Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes. Cell. 2021 04 15; 184(8):2239-2254.e39.
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Changes in the fine-scale genetic structure of Finland through the 20th century. PLoS Genet. 2021 03; 17(3):e1009347.
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Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla. Nat Commun. 2021 02 17; 12(1):1096.
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Accessible Pipeline for Translational Research Using TCGA: Examples of Relating Gene Mechanism to Disease-Specific Outcomes. Methods Mol Biol. 2021; 2194:127-142.