"Genetic Heterogeneity" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
Concept/Terms
Genetic Heterogeneity- Genetic Heterogeneity
- Heterogeneity, Genetic
- Genetic Heterogeneities
- Heterogeneities, Genetic
Below are MeSH descriptors whose meaning is more general than "Genetic Heterogeneity".
Below are MeSH descriptors whose meaning is more specific than "Genetic Heterogeneity".
This graph shows the total number of publications written about "Genetic Heterogeneity" by people in Harvard Catalyst Profiles by year, and whether "Genetic Heterogeneity" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 5 | 2 | 7 |
| 1996 | 2 | 3 | 5 |
| 1997 | 2 | 7 | 9 |
| 1998 | 4 | 4 | 8 |
| 1999 | 2 | 2 | 4 |
| 2000 | 4 | 6 | 10 |
| 2001 | 4 | 13 | 17 |
| 2002 | 3 | 8 | 11 |
| 2003 | 1 | 6 | 7 |
| 2004 | 2 | 6 | 8 |
| 2005 | 3 | 3 | 6 |
| 2006 | 1 | 7 | 8 |
| 2007 | 5 | 5 | 10 |
| 2008 | 3 | 5 | 8 |
| 2009 | 4 | 6 | 10 |
| 2010 | 5 | 5 | 10 |
| 2011 | 5 | 9 | 14 |
| 2012 | 7 | 9 | 16 |
| 2013 | 9 | 9 | 18 |
| 2014 | 12 | 20 | 32 |
| 2015 | 7 | 18 | 25 |
| 2016 | 8 | 17 | 25 |
| 2017 | 12 | 11 | 23 |
| 2018 | 8 | 12 | 20 |
| 2019 | 5 | 15 | 20 |
| 2020 | 7 | 11 | 18 |
| 2021 | 1 | 0 | 1 |
Below are the most recent publications written about "Genetic Heterogeneity" by people in Profiles.
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Single-cell transcriptional profiling of human thymic stroma uncovers novel cellular heterogeneity in the thymic medulla. Nat Commun. 2021 02 17; 12(1):1096.
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Single-cell RNA landscape of intratumoral heterogeneity and immunosuppressive microenvironment in advanced osteosarcoma. Nat Commun. 2020 12 10; 11(1):6322.
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Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity. Nat Genet. 2020 11; 52(11):1208-1218.
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Dental cell type atlas reveals stem and differentiated cell types in mouse and human teeth. Nat Commun. 2020 09 23; 11(1):4816.
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Human erythroleukemia genetics and transcriptomes identify master transcription factors as functional disease drivers. Blood. 2020 08 06; 136(6):698-714.
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Emergence of a High-Plasticity Cell State during Lung Cancer Evolution. Cancer Cell. 2020 08 10; 38(2):229-246.e13.
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Association of PIN3 16-bp duplication polymorphism of TP53 with breast cancer risk in Mali and a meta-analysis. BMC Med Genet. 2020 07 03; 21(1):142.
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Tau molecular diversity contributes to clinical heterogeneity in Alzheimer's disease. Nat Med. 2020 08; 26(8):1256-1263.
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Metabolic heterogeneity and adaptability in brain tumors. Cell Mol Life Sci. 2020 Dec; 77(24):5101-5119.
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Association of heterogeneous MYCN amplification with clinical features, biological characteristics and outcomes in neuroblastoma: A report from the Children's Oncology Group. Eur J Cancer. 2020 07; 133:112-119.