"Genes, src" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Retrovirus-associated DNA sequences (src) originally isolated from the Rous sarcoma virus (RSV). The proto-oncogene src (c-src) codes for a protein that is a member of the tyrosine kinase family and was the first proto-oncogene identified in the human genome. The human c-src gene is located at 20q12-13 on the long arm of chromosome 20.
MeSH Number(s)
G05.360.340.024.340.375.500.791.570
Concept/Terms
src Oncogene- src Oncogene
- Oncogene, src
- Oncogenes, src
- src Oncogenes
- v-src Oncogenes
- Oncogene, v-src
- Oncogenes, v-src
- v src Oncogenes
- v-src Oncogene
- v-src Genes
- Gene, v-src
- Genes, v-src
- v src Genes
- v-src Gene
c-src Genes- c-src Genes
- Gene, c-src
- Genes, c-src
- c src Genes
- c-src Gene
- c-src Proto-Oncogenes
- Proto-Oncogene, c-src
- Proto-Oncogenes, c-src
- c src Proto Oncogenes
- c-src Proto-Oncogene
Below are MeSH descriptors whose meaning is more general than "Genes, src".
Below are MeSH descriptors whose meaning is more specific than "Genes, src".
This graph shows the total number of publications written about "Genes, src" by people in Harvard Catalyst Profiles by year, and whether "Genes, src" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 3 | 2 | 5 |
| 1994 | 3 | 1 | 4 |
| 1995 | 1 | 2 | 3 |
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 1 | 1 |
| 1999 | 0 | 1 | 1 |
| 2000 | 1 | 0 | 1 |
| 2001 | 1 | 0 | 1 |
| 2002 | 1 | 1 | 2 |
| 2003 | 1 | 2 | 3 |
| 2004 | 1 | 1 | 2 |
| 2005 | 2 | 0 | 2 |
| 2006 | 1 | 0 | 1 |
| 2008 | 1 | 1 | 2 |
| 2009 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 1 | 1 |
| 2012 | 0 | 2 | 2 |
Below are the most recent publications written about "Genes, src" by people in Profiles.
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Src mutation induces acquired lapatinib resistance in ERBB2-amplified human gastroesophageal adenocarcinoma models. PLoS One. 2014; 9(10):e109440.
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Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer. PLoS One. 2012; 7(7):e41171.
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Ga12 activation in podocytes leads to cumulative changes in glomerular collagen expression, proteinuria and glomerulosclerosis. Lab Invest. 2012 May; 92(5):662-75.
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Slit2/Robo4 signaling modulates HIV-1 gp120-induced lymphatic hyperpermeability. PLoS Pathog. 2012 Jan; 8(1):e1002461.
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CD24 promotes tumor cell invasion by suppressing tissue factor pathway inhibitor-2 (TFPI-2) in a c-Src-dependent fashion. Clin Exp Metastasis. 2012 Jan; 29(1):27-38.
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Inhibition of miR-193a expression by Max and RXRa activates K-Ras and PLAU to mediate distinct aspects of cellular transformation. Cancer Res. 2011 Aug 01; 71(15):5144-53.
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STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer. Mol Cell. 2010 Aug 27; 39(4):493-506.
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An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation. Cell. 2009 Nov 13; 139(4):693-706.
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Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology. 2009 Feb 20; 384(2):304-16.
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Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma. Clin Cancer Res. 2008 Jul 01; 14(13):4284-91.