"Genes, rel" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Family of retrovirus-associated DNA sequences (v-rel) originally isolated from an avian reticuloendotheliosis virus strain. The proto-oncogene rel (c-rel) codes for a subcellular (nuclear and cytoplasmic) transcription factor that has a role in lymphocyte differentiation. Translocation or overexpression of c-rel or competition from v-rel causes oncogenesis. The human rel gene is located at 2p12-13 on the short arm of chromosome 2.
MeSH Number(s)
G05.360.340.024.340.375.500.791.552
Concept/Terms
v-rel Genes- v-rel Genes
- Gene, v-rel
- Genes, v-rel
- v rel Genes
- v-rel Gene
- v-rel Oncogenes
- Oncogene, v-rel
- Oncogenes, v-rel
- v rel Oncogenes
- v-rel Oncogene
- rel Oncogene
- Oncogene, rel
- Oncogenes, rel
- rel Oncogenes
c-rel Genes- c-rel Genes
- Gene, c-rel
- Genes, c-rel
- c rel Genes
- c-rel Gene
- c-rel Proto-Oncogenes
- Proto-Oncogene, c-rel
- Proto-Oncogenes, c-rel
- c rel Proto Oncogenes
- c-rel Proto-Oncogene
Below are MeSH descriptors whose meaning is more general than "Genes, rel".
Below are MeSH descriptors whose meaning is more specific than "Genes, rel".
This graph shows the total number of publications written about "Genes, rel" by people in Harvard Catalyst Profiles by year, and whether "Genes, rel" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 1 | 0 | 1 |
| 2002 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
Below are the most recent publications written about "Genes, rel" by people in Profiles.
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A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency. Blood. 2013 Nov 28; 122(23):3713-22.
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An investigation of rheumatoid arthritis loci in patients with early-onset psoriasis validates association of the REL gene. Br J Dermatol. 2013 Apr; 168(4):864-6.
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Genome-wide meta-analysis of psoriatic arthritis identifies susceptibility locus at REL. J Invest Dermatol. 2012 Apr; 132(4):1133-40.
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TNF-a promotes c-REL/?Np63a interaction and TAp73 dissociation from key genes that mediate growth arrest and apoptosis in head and neck cancer. Cancer Res. 2011 Nov 01; 71(21):6867-77.
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ERK and JNK activation is essential for oncogenic transformation by v-Rel. Oncogene. 2010 Nov 25; 29(47):6267-79.
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Confirmation of association of the REL locus with rheumatoid arthritis susceptibility in the UK population. Ann Rheum Dis. 2010 Aug; 69(8):1572-3.
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REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet. 2009 Jul; 41(7):820-3.
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NF-kappaB controls growth of glioblastomas/astrocytomas. Mol Cell Biochem. 2008 Jan; 307(1-2):141-7.
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The activation of TC10, a Rho small GTPase, contributes to v-Rel-mediated transformation. Oncogene. 2007 Apr 05; 26(16):2318-29.
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Unraveling androgen receptor interactomes by an array-based method: discovery of proto-oncoprotein c-Rel as a negative regulator of androgen receptor. Exp Cell Res. 2006 Nov 15; 312(19):3782-95.