Gene Rearrangement, B-Lymphocyte, Heavy Chain
"Gene Rearrangement, B-Lymphocyte, Heavy Chain" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Ordered rearrangement of B-lymphocyte variable gene regions of the IMMUNOGLOBULIN HEAVY CHAINS, thereby contributing to antibody diversity. It occurs during the first stage of differentiation of the IMMATURE B-LYMPHOCYTES.
MeSH Number(s)
G05.355.330.401.501
G12.425.742.500.501
G12.500.349.500.501
Concept/Terms
Gene Rearrangement, B-Lymphocyte, Heavy Chain- Gene Rearrangement, B-Lymphocyte, Heavy Chain
- B-Cell Heavy Chain Gene Rearrangement
- B-Lymphocyte Heavy Chain Gene Rearrangement
- B Cell Heavy Chain Gene Rearrangement
- B Lymphocyte Heavy Chain Gene Rearrangement
Below are MeSH descriptors whose meaning is more general than "Gene Rearrangement, B-Lymphocyte, Heavy Chain".
Below are MeSH descriptors whose meaning is more specific than "Gene Rearrangement, B-Lymphocyte, Heavy Chain".
This graph shows the total number of publications written about "Gene Rearrangement, B-Lymphocyte, Heavy Chain" by people in Harvard Catalyst Profiles by year, and whether "Gene Rearrangement, B-Lymphocyte, Heavy Chain" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 1 | 3 |
| 1994 | 1 | 3 | 4 |
| 1995 | 2 | 1 | 3 |
| 1997 | 2 | 0 | 2 |
| 1998 | 2 | 1 | 3 |
| 1999 | 2 | 0 | 2 |
| 2002 | 1 | 0 | 1 |
| 2003 | 1 | 0 | 1 |
| 2004 | 1 | 3 | 4 |
| 2005 | 2 | 2 | 4 |
| 2006 | 1 | 4 | 5 |
| 2007 | 1 | 1 | 2 |
| 2008 | 2 | 2 | 4 |
| 2009 | 1 | 1 | 2 |
| 2010 | 2 | 3 | 5 |
| 2011 | 2 | 0 | 2 |
| 2012 | 1 | 2 | 3 |
| 2013 | 2 | 0 | 2 |
| 2014 | 2 | 1 | 3 |
| 2015 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
Below are the most recent publications written about "Gene Rearrangement, B-Lymphocyte, Heavy Chain" by people in Profiles.
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Determination of VH Family Usage in B-Cell Malignancies via the BIOMED-2 IGH PCR Clonality Assay. Am J Clin Pathol. 2017 Jun 01; 147(6):549-556.
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A DNA target-enrichment approach to detect mutations, copy number changes and immunoglobulin translocations in multiple myeloma. Blood Cancer J. 2016 09 02; 6(9):e467.
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An Immunogenetic Signature of Ongoing Antigen Interactions in Splenic Marginal Zone Lymphoma Expressing IGHV1-2*04 Receptors. Clin Cancer Res. 2016 Apr 15; 22(8):2032-40.
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Setd1a regulates progenitor B-cell-to-precursor B-cell development through histone H3 lysine 4 trimethylation and Ig heavy-chain rearrangement. FASEB J. 2015 Apr; 29(4):1505-15.
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Not all IGHV3-21 chronic lymphocytic leukemias are equal: prognostic considerations. Blood. 2015 Jan 29; 125(5):856-9.
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Transformation of small B-cell lymphoma into large cell CD30?, CD4?, Epstein-Barr virus-negative lymphoma. Arch Pathol Lab Med. 2014 Aug; 138(8):1101-5.
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Flexible long-range loops in the VH gene region of the Igh locus facilitate the generation of a diverse antibody repertoire. Immunity. 2013 Aug 22; 39(2):229-44.
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Deep sequencing of the murine IgH repertoire reveals complex regulation of nonrandom V gene rearrangement frequencies. J Immunol. 2013 Sep 01; 191(5):2393-402.
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Localized DNA demethylation at recombination intermediates during immunoglobulin heavy chain gene assembly. PLoS Biol. 2013; 11(1):e1001475.
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Mantle cell lymphoma cell lines show no evident immunoglobulin heavy chain stereotypy but frequent light chain stereotypy. Leuk Lymphoma. 2013 Aug; 54(8):1747-55.