"Gene Dosage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
Concept/Terms
Gene Dosage- Gene Dosage
- Dosage, Gene
- Dosages, Gene
- Gene Dosages
- Gene Copy Number
- Copy Number, Gene
- Copy Numbers, Gene
- Gene Copy Numbers
- Number, Gene Copy
- Numbers, Gene Copy
Below are MeSH descriptors whose meaning is more general than "Gene Dosage".
Below are MeSH descriptors whose meaning is more specific than "Gene Dosage".
This graph shows the total number of publications written about "Gene Dosage" by people in Harvard Catalyst Profiles by year, and whether "Gene Dosage" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 2 | 3 | 5 |
| 1996 | 0 | 7 | 7 |
| 1997 | 2 | 7 | 9 |
| 1998 | 2 | 4 | 6 |
| 1999 | 3 | 7 | 10 |
| 2000 | 1 | 7 | 8 |
| 2001 | 1 | 20 | 21 |
| 2002 | 2 | 18 | 20 |
| 2003 | 2 | 10 | 12 |
| 2004 | 6 | 18 | 24 |
| 2005 | 5 | 14 | 19 |
| 2006 | 9 | 13 | 22 |
| 2007 | 11 | 14 | 25 |
| 2008 | 23 | 28 | 51 |
| 2009 | 20 | 27 | 47 |
| 2010 | 11 | 32 | 43 |
| 2011 | 16 | 35 | 51 |
| 2012 | 8 | 22 | 30 |
| 2013 | 8 | 26 | 34 |
| 2014 | 5 | 23 | 28 |
| 2015 | 9 | 21 | 30 |
| 2016 | 12 | 35 | 47 |
| 2017 | 9 | 17 | 26 |
| 2018 | 5 | 14 | 19 |
| 2019 | 3 | 10 | 13 |
| 2020 | 2 | 19 | 21 |
| 2021 | 2 | 9 | 11 |
| 2022 | 0 | 2 | 2 |
| 2023 | 0 | 1 | 1 |
Below are the most recent publications written about "Gene Dosage" by people in Profiles.
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Mono- and biallelic variant effects on disease at biobank scale. Nature. 2023 01; 613(7944):519-525.
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A cross-disorder dosage sensitivity map of the human genome. Cell. 2022 08 04; 185(16):3041-3055.e25.
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Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation. Am J Surg Pathol. 2022 03 01; 46(3):424-433.
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CCNE1 copy number is a biomarker for response to combination WEE1-ATR inhibition in ovarian and endometrial cancer models. Cell Rep Med. 2021 09 21; 2(9):100394.
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Locus specific epigenetic modalities of random allelic expression imbalance. Nat Commun. 2021 09 09; 12(1):5330.
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TNPO2 variants associate with human developmental delays, neurologic deficits, and dysmorphic features and alter TNPO2 activity in Drosophila. Am J Hum Genet. 2021 09 02; 108(9):1669-1691.
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Loss of the MAF Transcription Factor in Laryngeal Squamous Cell Carcinoma. Biomolecules. 2021 07 15; 11(7).
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Landscape of allele-specific transcription factor binding in the human genome. Nat Commun. 2021 05 12; 12(1):2751.
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Determination of complete chromosomal haplotypes by bulk DNA sequencing. Genome Biol. 2021 05 06; 22(1):139.
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Global miRNA dosage control of embryonic germ layer specification. Nature. 2021 05; 593(7860):602-606.