"Gene Dosage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
Concept/Terms
Gene Dosage- Gene Dosage
- Dosage, Gene
- Dosages, Gene
- Gene Dosages
- Gene Copy Number
- Copy Number, Gene
- Copy Numbers, Gene
- Gene Copy Numbers
- Number, Gene Copy
- Numbers, Gene Copy
Below are MeSH descriptors whose meaning is more general than "Gene Dosage".
Below are MeSH descriptors whose meaning is more specific than "Gene Dosage".
This graph shows the total number of publications written about "Gene Dosage" by people in Harvard Catalyst Profiles by year, and whether "Gene Dosage" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 2 | 3 | 5 |
| 1996 | 0 | 7 | 7 |
| 1997 | 2 | 7 | 9 |
| 1998 | 2 | 4 | 6 |
| 1999 | 3 | 8 | 11 |
| 2000 | 1 | 7 | 8 |
| 2001 | 1 | 20 | 21 |
| 2002 | 2 | 17 | 19 |
| 2003 | 2 | 10 | 12 |
| 2004 | 6 | 17 | 23 |
| 2005 | 5 | 13 | 18 |
| 2006 | 9 | 14 | 23 |
| 2007 | 11 | 14 | 25 |
| 2008 | 22 | 28 | 50 |
| 2009 | 22 | 28 | 50 |
| 2010 | 12 | 31 | 43 |
| 2011 | 14 | 34 | 48 |
| 2012 | 9 | 24 | 33 |
| 2013 | 7 | 27 | 34 |
| 2014 | 5 | 21 | 26 |
| 2015 | 9 | 22 | 31 |
| 2016 | 11 | 35 | 46 |
| 2017 | 9 | 16 | 25 |
| 2018 | 5 | 13 | 18 |
| 2019 | 3 | 10 | 13 |
| 2020 | 2 | 19 | 21 |
| 2021 | 1 | 6 | 7 |
| 2022 | 0 | 2 | 2 |
Below are the most recent publications written about "Gene Dosage" by people in Profiles.
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A cross-disorder dosage sensitivity map of the human genome. Cell. 2022 08 04; 185(16):3041-3055.e25.
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Pulmonary "Inflammatory Leiomyosarcomas" Are Indolent Tumors With Diploid Genomes and No Convincing Rhabdomyoblastic Differentiation. Am J Surg Pathol. 2022 03 01; 46(3):424-433.
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Locus specific epigenetic modalities of random allelic expression imbalance. Nat Commun. 2021 09 09; 12(1):5330.
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Loss of the MAF Transcription Factor in Laryngeal Squamous Cell Carcinoma. Biomolecules. 2021 07 15; 11(7).
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Landscape of allele-specific transcription factor binding in the human genome. Nat Commun. 2021 05 12; 12(1):2751.
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Global miRNA dosage control of embryonic germ layer specification. Nature. 2021 05; 593(7860):602-606.
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Medical Records-Based Genetic Studies of the Complement System. J Am Soc Nephrol. 2021 08; 32(8):2031-2047.
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Loss of SMAD4 Is Sufficient to Promote Tumorigenesis in a Model of Dysplastic Barrett's Esophagus. Cell Mol Gastroenterol Hepatol. 2021; 12(2):689-713.
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Population genomics and haplotype analysis in spelt and bread wheat identifies a gene regulating glume color. Commun Biol. 2021 03 19; 4(1):375.
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Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability. Mol Psychiatry. 2021 06; 26(6):2663-2676.