"Gene Dosage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
Concept/Terms
Gene Dosage- Gene Dosage
- Dosage, Gene
- Dosages, Gene
- Gene Dosages
- Gene Copy Number
- Copy Number, Gene
- Copy Numbers, Gene
- Gene Copy Numbers
- Number, Gene Copy
- Numbers, Gene Copy
Below are MeSH descriptors whose meaning is more general than "Gene Dosage".
Below are MeSH descriptors whose meaning is more specific than "Gene Dosage".
This graph shows the total number of publications written about "Gene Dosage" by people in Harvard Catalyst Profiles by year, and whether "Gene Dosage" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 2 | 3 | 5 |
| 1996 | 0 | 7 | 7 |
| 1997 | 2 | 8 | 10 |
| 1998 | 2 | 4 | 6 |
| 1999 | 3 | 7 | 10 |
| 2000 | 1 | 8 | 9 |
| 2001 | 1 | 19 | 20 |
| 2002 | 2 | 18 | 20 |
| 2003 | 3 | 10 | 13 |
| 2004 | 6 | 17 | 23 |
| 2005 | 5 | 12 | 17 |
| 2006 | 9 | 14 | 23 |
| 2007 | 11 | 15 | 26 |
| 2008 | 23 | 30 | 53 |
| 2009 | 21 | 30 | 51 |
| 2010 | 13 | 35 | 48 |
| 2011 | 15 | 38 | 53 |
| 2012 | 10 | 26 | 36 |
| 2013 | 8 | 32 | 40 |
| 2014 | 5 | 21 | 26 |
| 2015 | 11 | 27 | 38 |
| 2016 | 9 | 32 | 41 |
| 2017 | 9 | 17 | 26 |
| 2018 | 4 | 13 | 17 |
| 2019 | 2 | 14 | 16 |
| 2020 | 0 | 14 | 14 |
Below are the most recent publications written about "Gene Dosage" by people in Profiles.
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Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. Nat Neurosci. 2021 02; 24(2):214-224.
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Clinical Variability in Spinal Muscular Atrophy Type III. Ann Neurol. 2020 12; 88(6):1109-1117.
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Capmatinib in MET Exon 14-Mutated or MET-Amplified Non-Small-Cell Lung Cancer. N Engl J Med. 2020 09 03; 383(10):944-957.
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Genomic Predictors of Good Outcome, Recurrence, or Progression in High-Grade T1 Non-Muscle-Invasive Bladder Cancer. Cancer Res. 2020 10 15; 80(20):4476-4486.
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Stander Use in Spinal Muscular Atrophy: Results From a Large Natural History Database. Pediatr Phys Ther. 2020 07; 32(3):235-241.
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Biomarkers of aging and lung function in the normative aging study. Aging (Albany NY). 2020 06 19; 12(12):11942-11966.
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Mapping and characterization of structural variation in 17,795 human genomes. Nature. 2020 07; 583(7814):83-89.
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Mechanisms generating cancer genome complexity from a single cell division error. Science. 2020 04 17; 368(6488).
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Targeting the cyclin-dependent kinase 5 in metastatic melanoma. Proc Natl Acad Sci U S A. 2020 04 07; 117(14):8001-8012.
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The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020 03 18; 48(5):2621-2642.