"Gene Dosage" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
Concept/Terms
Gene Dosage- Gene Dosage
- Dosage, Gene
- Dosages, Gene
- Gene Dosages
- Gene Copy Number
- Copy Number, Gene
- Copy Numbers, Gene
- Gene Copy Numbers
- Number, Gene Copy
- Numbers, Gene Copy
Below are MeSH descriptors whose meaning is more general than "Gene Dosage".
Below are MeSH descriptors whose meaning is more specific than "Gene Dosage".
This graph shows the total number of publications written about "Gene Dosage" by people in Harvard Catalyst Profiles by year, and whether "Gene Dosage" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 2 | 2 |
| 1995 | 2 | 3 | 5 |
| 1996 | 0 | 7 | 7 |
| 1997 | 2 | 8 | 10 |
| 1998 | 2 | 4 | 6 |
| 1999 | 3 | 8 | 11 |
| 2000 | 1 | 7 | 8 |
| 2001 | 1 | 19 | 20 |
| 2002 | 2 | 17 | 19 |
| 2003 | 3 | 10 | 13 |
| 2004 | 6 | 17 | 23 |
| 2005 | 5 | 11 | 16 |
| 2006 | 9 | 13 | 22 |
| 2007 | 10 | 13 | 23 |
| 2008 | 22 | 29 | 51 |
| 2009 | 21 | 29 | 50 |
| 2010 | 12 | 31 | 43 |
| 2011 | 14 | 37 | 51 |
| 2012 | 9 | 26 | 35 |
| 2013 | 7 | 29 | 36 |
| 2014 | 5 | 23 | 28 |
| 2015 | 11 | 20 | 31 |
| 2016 | 10 | 32 | 42 |
| 2017 | 9 | 17 | 26 |
| 2018 | 5 | 13 | 18 |
| 2019 | 2 | 15 | 17 |
| 2020 | 2 | 20 | 22 |
| 2021 | 0 | 6 | 6 |
Below are the most recent publications written about "Gene Dosage" by people in Profiles.
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Locus specific epigenetic modalities of random allelic expression imbalance. Nat Commun. 2021 09 09; 12(1):5330.
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Landscape of allele-specific transcription factor binding in the human genome. Nat Commun. 2021 05 12; 12(1):2751.
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Medical Records-Based Genetic Studies of the Complement System. J Am Soc Nephrol. 2021 08; 32(8):2031-2047.
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Population genomics and haplotype analysis in spelt and bread wheat identifies a gene regulating glume color. Commun Biol. 2021 03 19; 4(1):375.
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Genome-wide analysis of gene dosage in 24,092 individuals estimates that 10,000 genes modulate cognitive ability. Mol Psychiatry. 2021 06; 26(6):2663-2676.
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Integrated Analysis of Germ Cell Tumors. Methods Mol Biol. 2021; 2195:181-187.
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Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice. Nat Neurosci. 2021 02; 24(2):214-224.
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Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease. Dev Cell. 2021 02 08; 56(3):292-309.e9.
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Targeted sequencing reveals the somatic mutation landscape in a Swedish breast cancer cohort. Sci Rep. 2020 11 09; 10(1):19304.
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Regulatory T Cell-Derived TGF-ß1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity. Immunity. 2020 12 15; 53(6):1202-1214.e6.