"Gene Conversion" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The asymmetrical segregation of genes during replication which leads to the production of non-reciprocal recombinant strands and the apparent conversion of one allele into another. Thus, e.g., the meiotic products of an Aa individual may be AAAa or aaaA instead of AAaa, i.e., the A allele has been converted into the a allele or vice versa.
Concept/Terms
Gene Conversion- Gene Conversion
- Conversion, Gene
- Conversions, Gene
- Gene Conversions
Polar Recombination- Polar Recombination
- Polar Recombinations
- Recombination, Polar
- Recombinations, Polar
Below are MeSH descriptors whose meaning is more general than "Gene Conversion".
Below are MeSH descriptors whose meaning is more specific than "Gene Conversion".
This graph shows the total number of publications written about "Gene Conversion" by people in Harvard Catalyst Profiles by year, and whether "Gene Conversion" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 1 | 0 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 2 | 3 |
| 2002 | 0 | 2 | 2 |
| 2003 | 4 | 1 | 5 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 1 | 2 |
| 2006 | 1 | 1 | 2 |
| 2007 | 0 | 1 | 1 |
| 2008 | 1 | 3 | 4 |
| 2009 | 1 | 3 | 4 |
| 2011 | 1 | 0 | 1 |
| 2013 | 3 | 0 | 3 |
| 2014 | 0 | 3 | 3 |
| 2016 | 1 | 2 | 3 |
| 2017 | 1 | 1 | 2 |
| 2019 | 1 | 0 | 1 |
| 2021 | 3 | 3 | 6 |
| 2022 | 1 | 2 | 3 |
Below are the most recent publications written about "Gene Conversion" by people in Profiles.
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Frequent somatic gene conversion as a mechanism for loss of heterozygosity in tumor suppressor genes. Genome Res. 2022 06; 32(6):1017-1025.
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Somatic Diversification of Rearranged Antibody Gene Segments by Intra- and Interchromosomal Templated Mutagenesis. J Immunol. 2022 05 01; 208(9):2141-2153.
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BRCA1 deficiency specific base substitution mutagenesis is dependent on translesion synthesis and regulated by 53BP1. Nat Commun. 2022 01 11; 13(1):226.
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Meiotic Cas9 expression mediates gene conversion in the male and female mouse germline. PLoS Biol. 2021 12; 19(12):e3001478.
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Applications of and considerations for using CRISPR-Cas9-mediated gene conversion systems in rodents. Nat Protoc. 2022 01; 17(1):3-14.
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GC-biased gene conversion in X-chromosome palindromes conserved in human, chimpanzee, and rhesus macaque. G3 (Bethesda). 2021 10 19; 11(11).
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Implications of mosaicism in variant interpretation: A case of a de novo homozygous NF1 variant. Eur J Med Genet. 2021 Jul; 64(7):104236.
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Deleterious mutation accumulation and the long-term fate of chromosomal inversions. PLoS Genet. 2021 03; 17(3):e1009411.
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Replication-independent instability of Friedreich's ataxia GAA repeats during chronological aging. Proc Natl Acad Sci U S A. 2021 02 02; 118(5).
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Detection of SMN1 to SMN2 gene conversion events and partial SMN1 gene deletions using array digital PCR. Neurogenetics. 2021 03; 22(1):53-64.