Furin

"Furin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A proprotein convertase with specificity for the proproteins of PROALBUMIN; COMPLEMENT 3C; and VON WILLEBRAND FACTOR. It has specificity for cleavage near paired ARGININE residues that are separated by two amino acids.

Descriptor ID

D045683

MeSH Number(s)

D08.811.277.656.300.760.353

D08.811.277.656.837.249

D08.811.277.656.959.350.353

Concept/Terms

Furin

Below are MeSH descriptors whose meaning is more general than "Furin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Furin [D08.811.277.656.300.760.353]
Proprotein Convertases [D08.811.277.656.837]
Furin [D08.811.277.656.837.249]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Furin [D08.811.277.656.959.350.353]

Below are MeSH descriptors whose meaning is related to "Furin".

Below are MeSH descriptors whose meaning is more specific than "Furin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Furin" by people in Harvard Catalyst Profiles by year, and whether "Furin" was a major or minor topic of these publication.

Bar chart showing 27 publications over 17 distinct years, with a maximum of 3 publications in 2020 and 2021

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1997	0	1	1
1999	0	1	1
2001	0	1	1
2003	0	2	2
2004	1	0	1
2007	0	1	1
2009	0	1	1
2010	0	1	1
2011	0	1	1
2013	1	0	1
2014	1	1	2
2015	1	1	2
2018	0	2	2
2020	1	2	3
2021	1	2	3
2022	0	2	2
2023	2	0	2

Below are the most recent publications written about "Furin" by people in Profiles.

Cryptococcal proteases exhibit the potential to activate the latent SARS-CoV-2 spike protein. J Infect Public Health. 2024 Feb; 17(2):263-270.

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1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage. JCI Insight. 2023 09 08; 8(17).

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SARS-CoV-2 requires acidic pH to infect cells. Proc Natl Acad Sci U S A. 2022 09 20; 119(38):e2209514119.

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Cryptococcal Protease(s) and the Activation of SARS-CoV-2 Spike (S) Protein. Cells. 2022 01 27; 11(3).

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SARS-CoV-2 Bearing a Mutation at the S1/S2 Cleavage Site Exhibits Attenuated Virulence and Confers Protective Immunity. mBio. 2021 08 31; 12(4):e0141521.

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Targeting Runt-Related Transcription Factor 1 Prevents Pulmonary Fibrosis and Reduces Expression of Severe Acute Respiratory Syndrome Coronavirus 2 Host Mediators. Am J Pathol. 2021 07; 191(7):1193-1208.

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Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection. Stem Cell Reports. 2021 03 09; 16(3):505-518.

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In well-differentiated primary human bronchial epithelial cells, TGF-ß1 and TGF-ß2 induce expression of furin. Am J Physiol Lung Cell Mol Physiol. 2021 02 01; 320(2):L246-L253.

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A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice. Immunity. 2020 10 13; 53(4):724-732.e7.

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ELA/APELA precursor cleaved by furin displays tumor suppressor function in renal cell carcinoma through mTORC1 activation. JCI Insight. 2020 07 23; 5(14).

View in: PubMed

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