Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Freeze Etching

"Freeze Etching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

A replica technique in which cells are frozen to a very low temperature and cracked with a knife blade to expose the interior surfaces of the cells or cell membranes. The cracked cell surfaces are then freeze-dried to expose their constituents. The surfaces are now ready for shadowing to be viewed using an electron microscope. This method differs from freeze-fracturing in that no cryoprotectant is used and, thus, allows for the sublimation of water during the freeze-drying process to etch the surfaces.


This graph shows the total number of publications written about "Freeze Etching" by people in Harvard Catalyst Profiles by year, and whether "Freeze Etching" was a major or minor topic of these publication.
Bar chart showing 5 publications over 5 distinct years, with a maximum of 1 publications in 1991 and 1995 and 1998 and 2003 and 2005
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.