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Freeze Etching

"Freeze Etching" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information
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A replica technique in which cells are frozen to a very low temperature and cracked with a knife blade to expose the interior surfaces of the cells or cell membranes. The cracked cell surfaces are then freeze-dried to expose their constituents. The surfaces are now ready for shadowing to be viewed using an electron microscope. This method differs from freeze-fracturing in that no cryoprotectant is used and, thus, allows for the sublimation of water during the freeze-drying process to etch the surfaces.


publications
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This graph shows the total number of publications written about "Freeze Etching" by people in Harvard Catalyst Profiles by year, and whether "Freeze Etching" was a major or minor topic of these publication.
Bar chart showing 4 publications over 4 distinct years, with a maximum of 1 publications in 1995 and 1998 and 2003 and 2005
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.