Follistatin

"Follistatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A broadly distributed protein that binds directly to ACTIVINS. It functions as an activin antagonist, inhibits FOLLICLE STIMULATING HORMONE secretion, regulates CELL DIFFERENTIATION, and plays an important role in embryogenesis. Follistatin is a single glycosylated polypeptide chain of approximately 37-kDa and is not a member of the inhibin family (INHIBINS). Follistatin also binds and neutralizes many members of the TRANSFORMING GROWTH FACTOR BETA family.

Descriptor ID

D038681

MeSH Number(s)

D12.776.157.247

Concept/Terms

Follistatin

Below are MeSH descriptors whose meaning is more general than "Follistatin".

Chemicals and Drugs [D]
Amino Acids, Peptides, and Proteins [D12]
Proteins [D12.776]
Carrier Proteins [D12.776.157]
Follistatin [D12.776.157.247]

Below are MeSH descriptors whose meaning is related to "Follistatin".

Below are MeSH descriptors whose meaning is more specific than "Follistatin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Follistatin" by people in Harvard Catalyst Profiles by year, and whether "Follistatin" was a major or minor topic of these publication.

Bar chart showing 80 publications over 29 distinct years, with a maximum of 5 publications in 2016 and 2018 and 2019

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	0	2	2
1995	0	2	2
1996	0	4	4
1997	0	2	2
1998	0	2	2
1999	0	1	1
2000	0	4	4
2001	0	3	3
2002	0	3	3
2003	1	0	1
2004	3	1	4
2006	1	0	1
2007	0	3	3
2008	3	0	3
2009	1	1	2
2010	1	1	2
2011	4	0	4
2012	1	2	3
2013	1	1	2
2014	1	0	1
2016	4	1	5
2017	3	1	4
2018	5	0	5
2019	2	3	5
2020	1	1	2
2021	2	0	2
2022	2	1	3
2023	0	4	4
2024	0	1	1

Below are the most recent publications written about "Follistatin" by people in Profiles.

Circulating Growth Differentiation Factors 11 and 8, Their Antagonists Follistatin and Follistatin-Like-3, and Risk of Heart Failure in Elders. J Gerontol A Biol Sci Med Sci. 2024 Jan 01; 79(1).

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Evaluation of Associations of Growth Differentiation Factor-11, Growth Differentiation Factor-8, and Their Binding Proteins, Follistatin and Follistatin-Like Protein-3, With Measures of Skeletal Muscle Mass, Muscle Strength, and Physical Function in Older Adults. J Gerontol A Biol Sci Med Sci. 2023 10 28; 78(11):2051-2059.

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Circulating hormones in biopsy-proven steatotic liver disease and steatohepatitis: A Multicenter Observational Study. Metabolism. 2023 11; 148:155694.

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Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction. Nat Commun. 2023 08 03; 14(1):4417.

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Hepatic follistatin increases basal metabolic rate and attenuates diet-induced obesity during hepatic insulin resistance. Mol Metab. 2023 05; 71:101703.

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Activins, follistatins and inhibins in postmenopausal osteoporosis: A proof of concept, case-control study. Metabolism. 2023 04; 141:155397.

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Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration. Nat Commun. 2022 Nov 21; 13(1):7058.

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Embryo Quality May Be Associated With Serum Inhibin B Levels but Not With Serum or Follicular Fluid Levels of Other Components of the Activin-Follistatin-Inhibin Axis. Endocr Pract. 2022 Oct; 28(10):1086-1090.

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Elevated circulating follistatin associates with an increased risk of type 2 diabetes. Nat Commun. 2021 11 10; 12(1):6486.

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Serum Follistatin Is Increased in Thyroid Cancer and Is Associated With Adverse Tumor Characteristics in Humans. J Clin Endocrinol Metab. 2021 04 23; 106(5):e2137-e2150.

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