Harvard Catalyst Profiles

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Flap Endonucleases

"Flap Endonucleases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

Endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick.


This graph shows the total number of publications written about "Flap Endonucleases" by people in Harvard Catalyst Profiles by year, and whether "Flap Endonucleases" was a major or minor topic of these publication.
Bar chart showing 12 publications over 10 distinct years, with a maximum of 2 publications in 2009 and 2014
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.