Fibrinolysin

"Fibrinolysin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.

Descriptor ID

D005341

MeSH Number(s)

D08.811.277.656.300.760.330

D08.811.277.656.959.350.330

Concept/Terms

Fibrinolysin

Fibrogammin

Thrombolysin

Below are MeSH descriptors whose meaning is more general than "Fibrinolysin".

Chemicals and Drugs [D]
Enzymes and Coenzymes [D08]
Enzymes [D08.811]
Hydrolases [D08.811.277]
Peptide Hydrolases [D08.811.277.656]
Endopeptidases [D08.811.277.656.300]
Serine Endopeptidases [D08.811.277.656.300.760]
Fibrinolysin [D08.811.277.656.300.760.330]
Serine Proteases [D08.811.277.656.959]
Serine Endopeptidases [D08.811.277.656.959.350]
Fibrinolysin [D08.811.277.656.959.350.330]

Below are MeSH descriptors whose meaning is more specific than "Fibrinolysin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Fibrinolysin" by people in Harvard Catalyst Profiles by year, and whether "Fibrinolysin" was a major or minor topic of these publication.

Bar chart showing 60 publications over 27 distinct years, with a maximum of 4 publications in 2010 and 2013 and 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	2	1	3
1995	1	2	3
1996	0	2	2
1997	1	1	2
1999	0	2	2
2000	2	0	2
2001	0	1	1
2002	1	2	3
2003	0	3	3
2004	0	3	3
2005	0	2	2
2006	1	0	1
2007	1	1	2
2008	1	1	2
2009	1	1	2
2010	3	1	4
2011	1	1	2
2013	1	3	4
2014	3	1	4
2015	3	0	3
2016	1	2	3
2017	1	0	1
2018	1	0	1
2019	0	1	1
2020	0	1	1
2021	2	0	2
2022	0	1	1

Below are the most recent publications written about "Fibrinolysin" by people in Profiles.

COMBINED PNEUMATIC AND ENZYMATIC VITREOLYSIS FOR SEVERE CASES OF VITREOMACULAR TRACTION. Retin Cases Brief Rep. 2022 Sep 01; 16(5):631-636.

View in: PubMed
Insufficiency of hepatocyte growth factor activator inhibitor-1 confers lymphatic invasion of tongue carcinoma cells. Cancer Sci. 2022 Jun; 113(6):2179-2193.

View in: PubMed
Heparin and Arginine Based Plasmin Nanoformulation for Ischemic Stroke Therapy. Int J Mol Sci. 2021 Oct 25; 22(21).

View in: PubMed
Increased plasmin-mediated proteolysis of L1CAM in a mouse model of idiopathic normal pressure hydrocephalus. Proc Natl Acad Sci U S A. 2021 08 17; 118(33).

View in: PubMed
Plasmin thrombelastography rapidly identifies trauma patients at risk for massive transfusion, mortality, and hyperfibrinolysis: A diagnostic tool to resolve an international debate on tranexamic acid? J Trauma Acute Care Surg. 2020 12; 89(6):991-998.

View in: PubMed
Tranexamic acid mediates proinflammatory and anti-inflammatory signaling via complement C5a regulation in a plasminogen activator-dependent manner. J Trauma Acute Care Surg. 2019 01; 86(1):101-107.

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Ocriplasmin Treatment Leads to Symptomatic Vitreomacular Adhesion/Vitreomacular Traction Resolution in the Real-World Setting: The Phase IV ORBIT Study. Ophthalmol Retina. 2019 01; 3(1):32-41.

View in: PubMed
A targeted ferritin-microplasmin based thrombolytic nanocage selectively dissolves blood clots. Nanomedicine. 2018 04; 14(3):633-642.

View in: PubMed
Impact of Preinjection Spectral Domain Optical Coherence Tomography Findings in the Use of Intravitreal Ocriplasmin in a Clinical Setting. Ophthalmologica. 2018; 239(1):11-18.

View in: PubMed
The role of plasmin in the pathogenesis of murine multiple myeloma. Biochem Biophys Res Commun. 2017 06 24; 488(2):387-392.

View in: PubMed

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