"Fibrinogens, Abnormal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Fibrinogens which have a functional defect as the result of one or more amino acid substitutions in the amino acid sequence of normal fibrinogen. Abnormalities of the fibrinogen molecule may impair any of the major steps involved in the conversion of fibrinogen into stabilized fibrin, such as cleavage of the fibrinopeptides by thrombin, polymerization and cross-linking of fibrin. The resulting dysfibrinogenemias can be clinically silent or can be associated with bleeding, thrombosis or defective wound healing.
MeSH Number(s)
D12.776.124.050.250.265
D12.776.124.125.500.265
D23.119.490.265
Below are MeSH descriptors whose meaning is more general than "Fibrinogens, Abnormal".
Below are MeSH descriptors whose meaning is more specific than "Fibrinogens, Abnormal".
This graph shows the total number of publications written about "Fibrinogens, Abnormal" by people in Harvard Catalyst Profiles by year, and whether "Fibrinogens, Abnormal" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 2 | 0 | 2 |
| 2012 | 0 | 1 | 1 |
| 2015 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
Below are the most recent publications written about "Fibrinogens, Abnormal" by people in Profiles.
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Fibrinogen Columbus III: A novel c.963del frameshift mutation in the FGG gene resulting in hypofibrinogenemia with a bleeding phenotype. Pediatr Blood Cancer. 2021 03; 68(3):e28713.
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Fibrinogen Columbus II: A novel c.1075G>T mutation in the FGG gene causing hypodysfibrinogenemia and thrombosis in an adolescent male. Pediatr Blood Cancer. 2019 09; 66(9):e27832.
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Hepatic fibrinogen storage disease: identification of two novel mutations (p.Asp316Asn, fibrinogen Pisa and p.Gly366Ser, fibrinogen Beograd) impacting on the fibrinogen ?-module. J Thromb Haemost. 2015 Aug; 13(8):1459-67.
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[Cutaneous manifestations revealing cryofibrinogenaemia associated with monoclonal gammopathy]. Ann Dermatol Venereol. 2013 Jan; 140(1):30-5.
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[Genotype and function analyses of four inherited dysfibrinogenemia pedigree caused by Arg16 amino acid substitution in fibrinogen Aa chain]. Zhonghua Xue Ye Xue Za Zhi. 2012 Jun; 33(6):475-9.
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Long-term outcome of liver disease-related fibrinogen aguadilla storage disease in a child. J Pediatr Gastroenterol Nutr. 2011 Dec; 53(6):699.
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Assessment of genetic determinants of the association of ?' fibrinogen in relation to cardiovascular disease. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2345-52.
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Impaired protofibril formation in fibrinogen gamma N308K is due to altered D:D and "A:a" interactions. Biochemistry. 2009 Sep 15; 48(36):8656-63.
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High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension. Blood. 2009 Aug 27; 114(9):1929-36.
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Polymerization-defective fibrinogen variant gammaD364A binds knob "A" peptide mimic. Biochemistry. 2008 Aug 19; 47(33):8607-13.