Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
"Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enkephalin analog that selectively binds to the MU OPIOID RECEPTOR. It is used as a model for drug permeability experiments.
MeSH Number(s)
D12.644.400.575.281.075
D12.644.468.281.075
D12.776.641.650.575.281.075
Concept/Terms
Enkephalin, Ala(2)-MePhe(4)-Gly(5)-- Enkephalin, Ala(2)-MePhe(4)-Gly(5)-
- Tyr-Ala-Gly-(NMe)Phe-Gly-ol
- 2-Ala-4-MePhe-5-Gly-Enkephalin
- 2 Ala 4 MePhe 5 Gly Enkephalin
- Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- D-Ala(2)-MePhe(4)-Gly-ol(5) Enkephalin
- DAMGO
- DAGO
- DAGOL
- DAMGE
- Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-
- D-Ala2-NMe-Phe4-Gly-ol Enkephalin
- D Ala2 NMe Phe4 Gly ol Enkephalin
- Enkephalin, D-Ala2-NMe-Phe4-Gly-ol
Below are MeSH descriptors whose meaning is more general than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
Below are MeSH descriptors whose meaning is more specific than "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-".
This graph shows the total number of publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in Harvard Catalyst Profiles by year, and whether "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" was a major or minor topic of these publication.
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Year | Major Topic | Minor Topic | Total |
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1993 | 0 | 1 | 1 |
1994 | 0 | 1 | 1 |
1995 | 0 | 2 | 2 |
1996 | 0 | 2 | 2 |
1997 | 0 | 3 | 3 |
1998 | 0 | 3 | 3 |
1999 | 0 | 1 | 1 |
2000 | 1 | 1 | 2 |
2002 | 1 | 0 | 1 |
2003 | 0 | 3 | 3 |
2005 | 0 | 1 | 1 |
2006 | 0 | 1 | 1 |
2008 | 0 | 1 | 1 |
2009 | 0 | 1 | 1 |
2013 | 0 | 1 | 1 |
2014 | 0 | 1 | 1 |
2017 | 0 | 1 | 1 |
Below are the most recent publications written about "Enkephalin, Ala(2)-MePhe(4)-Gly(5)-" by people in Profiles.
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A Caged Enkephalin Optimized for Simultaneously Probing Mu and Delta Opioid Receptors. ACS Chem Neurosci. 2018 04 18; 9(4):684-690.
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Sex Differences in µ-Opioid Receptor Regulation of the Rat Locus Coeruleus and Their Cognitive Consequences. Neuropsychopharmacology. 2017 May; 42(6):1295-1304.
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Role of G Protein-Coupled Receptor Kinases 2 and 3 in µ-Opioid Receptor Desensitization and Internalization. Mol Pharmacol. 2015 Aug; 88(2):347-56.
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GINIP, a Gai-interacting protein, functions as a key modulator of peripheral GABAB receptor-mediated analgesia. Neuron. 2014 Oct 01; 84(1):123-136.
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Morphine-induced trafficking of a mu-opioid receptor interacting protein in rat locus coeruleus neurons. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Apr 03; 50:53-65.
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Caged naloxone reveals opioid signaling deactivation kinetics. Mol Pharmacol. 2013 Nov; 84(5):687-95.
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Ethanol reversal of cellular tolerance to morphine in rat locus coeruleus neurons. Mol Pharmacol. 2013 Aug; 84(2):252-60.
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Opioid-related (ORL1) receptors are enriched in a subpopulation of sensory neurons and prolonged activation produces no functional loss of surface N-type calcium channels. J Physiol. 2012 Apr 01; 590(7):1655-67.
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Standard opioid agonists activate heteromeric opioid receptors: evidence for morphine and [d-Ala(2)-MePhe(4)-Glyol(5)]enkephalin as selective µ-d agonists. ACS Chem Neurosci. 2010 Feb 17; 1(2):146-54.
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Opioids in the hypothalamic paraventricular nucleus stimulate ethanol intake. Alcohol Clin Exp Res. 2010 Feb; 34(2):214-22.