Encephalomyelitis, Autoimmune, Experimental
"Encephalomyelitis, Autoimmune, Experimental" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An experimental animal model for central nervous system demyelinating disease. Inoculation with a white matter emulsion combined with FREUND'S ADJUVANT, myelin basic protein, or purified central myelin triggers a T cell-mediated immune response directed towards central myelin. The pathologic features are similar to MULTIPLE SCLEROSIS, including perivascular and periventricular foci of inflammation and demyelination. Subpial demyelination underlying meningeal infiltrations also occurs, which is also a feature of ENCEPHALOMYELITIS, ACUTE DISSEMINATED. Passive immunization with T-cells from an afflicted animal to a normal animal also induces this condition. (From Immunol Res 1998;17(1-2):217-27; Raine CS, Textbook of Neuropathology, 2nd ed, p604-5)
MeSH Number(s)
C10.114.703.300
C10.228.140.695.562.250
C10.228.518.562.250
C10.314.350.250
C20.111.258.625.300
E05.598.500.500.500
Concept/Terms
Encephalomyelitis, Autoimmune, Experimental- Encephalomyelitis, Autoimmune, Experimental
- Allergic Encephalomyelitis, Experimental
- Encephalomyelitis, Experimental Allergic
- Experimental Allergic Encephalomyelitides
- Autoimmune Encephalomyelitis, Experimental
- Experimental Autoimmune Encephalomyelitis
- Encephalomyelitis, Allergic
- Encephalomyelitis, Experimental Autoimmune
- Experimental Allergic Encephalomyelitis
- Allergic Encephalomyelitis
- Autoimmune Experimental Encephalomyelitis
- Encephalomyelitis, Autoimmune Experimental
- Experimental Encephalomyelitis, Autoimmune
Below are MeSH descriptors whose meaning is more general than "Encephalomyelitis, Autoimmune, Experimental".
- Diseases [C]
- Nervous System Diseases [C10]
- Autoimmune Diseases of the Nervous System [C10.114]
- Nervous System Autoimmune Disease, Experimental [C10.114.703]
- Encephalomyelitis, Autoimmune, Experimental [C10.114.703.300]
- Central Nervous System Diseases [C10.228]
- Brain Diseases [C10.228.140]
- Leukoencephalopathies [C10.228.140.695]
- Demyelinating Autoimmune Diseases, CNS [C10.228.140.695.562]
- Encephalomyelitis, Autoimmune, Experimental [C10.228.140.695.562.250]
- Leukoencephalopathies [C10.228.518]
- Demyelinating Autoimmune Diseases, CNS [C10.228.518.562]
- Encephalomyelitis, Autoimmune, Experimental [C10.228.518.562.250]
- Demyelinating Diseases [C10.314]
- Demyelinating Autoimmune Diseases, CNS [C10.314.350]
- Encephalomyelitis, Autoimmune, Experimental [C10.314.350.250]
- Immune System Diseases [C20]
- Autoimmune Diseases [C20.111]
- Autoimmune Diseases of the Nervous System [C20.111.258]
- Nervous System Autoimmune Disease, Experimental [C20.111.258.625]
- Encephalomyelitis, Autoimmune, Experimental [C20.111.258.625.300]
- Analytical, Diagnostic and Therapeutic Techniques and Equipment [E]
- Investigative Techniques [E05]
- Models, Animal [E05.598]
- Disease Models, Animal [E05.598.500]
- Nervous System Autoimmune Disease, Experimental [E05.598.500.500]
- Encephalomyelitis, Autoimmune, Experimental [E05.598.500.500.500]
Below are MeSH descriptors whose meaning is more specific than "Encephalomyelitis, Autoimmune, Experimental".
This graph shows the total number of publications written about "Encephalomyelitis, Autoimmune, Experimental" by people in Harvard Catalyst Profiles by year, and whether "Encephalomyelitis, Autoimmune, Experimental" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1992 | 7 | 1 | 8 |
| 1993 | 6 | 1 | 7 |
| 1994 | 8 | 1 | 9 |
| 1995 | 5 | 4 | 9 |
| 1996 | 11 | 2 | 13 |
| 1997 | 5 | 1 | 6 |
| 1998 | 10 | 1 | 11 |
| 1999 | 9 | 3 | 12 |
| 2000 | 8 | 4 | 12 |
| 2001 | 11 | 4 | 15 |
| 2002 | 4 | 5 | 9 |
| 2003 | 11 | 5 | 16 |
| 2004 | 11 | 7 | 18 |
| 2005 | 9 | 2 | 11 |
| 2006 | 8 | 2 | 10 |
| 2007 | 14 | 5 | 19 |
| 2008 | 15 | 7 | 22 |
| 2009 | 14 | 2 | 16 |
| 2010 | 13 | 5 | 18 |
| 2011 | 11 | 8 | 19 |
| 2012 | 13 | 1 | 14 |
| 2013 | 10 | 9 | 19 |
| 2014 | 12 | 9 | 21 |
| 2015 | 19 | 7 | 26 |
| 2016 | 15 | 10 | 25 |
| 2017 | 7 | 4 | 11 |
| 2018 | 13 | 3 | 16 |
| 2019 | 19 | 3 | 22 |
| 2020 | 4 | 4 | 8 |
| 2021 | 13 | 6 | 19 |
| 2022 | 2 | 0 | 2 |
Below are the most recent publications written about "Encephalomyelitis, Autoimmune, Experimental" by people in Profiles.
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Treatment of Experimental Autoimmune Encephalomyelitis with an Inhibitor of Phosphodiesterase-8 (PDE8). Cells. 2022 02 14; 11(4).
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CCR6 and CXCR6 Identify the Th17 Cells With Cytotoxicity in Experimental Autoimmune Encephalomyelitis. Front Immunol. 2022; 13:819224.
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Stem-like intestinal Th17 cells give rise to pathogenic effector T cells during autoimmunity. Cell. 2021 12 22; 184(26):6281-6298.e23.
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CD47 antibody blockade suppresses microglia-dependent phagocytosis and monocyte transition to macrophages, impairing recovery in EAE. JCI Insight. 2021 11 08; 6(21).
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d-mannose suppresses oxidative response and blocks phagocytosis in experimental neuroinflammation. Proc Natl Acad Sci U S A. 2021 11 02; 118(44).
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Cold exposure protects from neuroinflammation through immunologic reprogramming. Cell Metab. 2021 11 02; 33(11):2231-2246.e8.
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ACKR1 favors transcellular over paracellular T-cell diapedesis across the blood-brain barrier in neuroinflammation in vitro. Eur J Immunol. 2022 01; 52(1):161-177.
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Metabolic modeling of single Th17 cells reveals regulators of autoimmunity. Cell. 2021 08 05; 184(16):4168-4185.e21.
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Induction of antigen-specific tolerance by nanobody-antigen adducts that target class-II major histocompatibility complexes. Nat Biomed Eng. 2021 11; 5(11):1389-1401.
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Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome. Cell Rep. 2021 06 01; 35(9):109201.