Doxepin

"Doxepin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.

Descriptor ID

D004316

MeSH Number(s)

D02.355.291.852.500

D03.494.382.393

Concept/Terms

Doxepin Hydrochloride

Below are MeSH descriptors whose meaning is more general than "Doxepin".

Chemicals and Drugs [D]
Organic Chemicals [D02]
Ethers [D02.355]
Ethers, Cyclic [D02.355.291]
Oxepins [D02.355.291.852]
Doxepin [D02.355.291.852.500]
Heterocyclic Compounds [D03]
Heterocyclic Compounds, 3-Ring [D03.494]
Dibenzoxepins [D03.494.382]
Doxepin [D03.494.382.393]

Below are MeSH descriptors whose meaning is related to "Doxepin".

Below are MeSH descriptors whose meaning is more specific than "Doxepin".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Doxepin" by people in Harvard Catalyst Profiles by year, and whether "Doxepin" was a major or minor topic of these publication.

Bar chart showing 9 publications over 8 distinct years, with a maximum of 2 publications in 1999

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
1994	1	0	1
1995	1	0	1
1998	0	1	1
1999	2	0	2
2004	1	0	1
2006	1	0	1
2007	0	1	1
2023	0	1	1

Below are the most recent publications written about "Doxepin" by people in Profiles.

Chronic Doxepin Toxicity Masquerading as Epilepsy in a 10-Year-Old Boy. J Med Toxicol. 2023 10; 19(4):405-410.

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Resiniferatoxin combined with antidepressants preferentially prolongs sensory/nociceptive block in rat sciatic nerve. Anesth Analg. 2010 Jul; 111(1):207-13.

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Differential neurotoxicity of tricyclic antidepressants and novel derivatives in vitro in a dorsal root ganglion cell culture model. Eur J Anaesthesiol. 2007 Aug; 24(8):702-8.

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Doxepin by topical application and intrathecal route in rats. Anesth Analg. 2006 Jan; 102(1):283-7.

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Differential block of N-propyl derivatives of amitriptyline and doxepin for sciatic nerve block in rats. Reg Anesth Pain Med. 2005 Jul-Aug; 30(4):344-50.

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Local anesthetic properties of a novel derivative, N-methyl doxepin, versus doxepin and bupivacaine. Anesth Analg. 2004 Mar; 98(3):672-6, table of contents.

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Tricyclic antidepressants as long-acting local anesthetics. Pain. 2003 May; 103(1-2):49-55.

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Pharmacokinetics of doxepin in subjects with pruritic atopic dermatitis. J Am Acad Dermatol. 1999 Aug; 41(2 Pt 1):209-14.

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The addition of topical doxepin to corticosteroid therapy: an improved treatment regimen for atopic dermatitis. Int J Dermatol. 1999 Feb; 38(2):145-8.

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I read in your June 1997 publication that one of the risk factors for hip fracture is current use of long-acting benzodiazepines. Could you list exactly which medications these are? I take Xanax and doxepin for fibromyalgia. My pharmacist could find no evidence that either of these drugs depletes bone calcium. How do they place me at increased risk for osteoporosis? Harv Womens Health Watch. 1998 Jan; 5(5):8.

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