Dosage Compensation, Genetic
"Dosage Compensation, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.
Concept/Terms
Dosage Compensation, Genetic- Dosage Compensation, Genetic
- Compensation, Genetic Dosage
- Genetic Dosage Compensation
- Genetic Dosage Compensations
- Gene Dosage Compensation
- Compensation, Gene Dosage
- Dosage Compensation, Gene
- Gene Dosage Compensations
- Dosage Compensation (Genetics)
- Compensation, Dosage (Genetics)
X-Chromosome Hypertranscription- X-Chromosome Hypertranscription
- X Chromosome Hypertranscription
- Hypertranscription, X-Chromosome
- Hypertranscription, X Chromosome
Below are MeSH descriptors whose meaning is more general than "Dosage Compensation, Genetic".
Below are MeSH descriptors whose meaning is more specific than "Dosage Compensation, Genetic".
This graph shows the total number of publications written about "Dosage Compensation, Genetic" by people in Harvard Catalyst Profiles by year, and whether "Dosage Compensation, Genetic" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1993 | 2 | 4 | 6 |
| 1994 | 4 | 4 | 8 |
| 1995 | 7 | 2 | 9 |
| 1996 | 3 | 0 | 3 |
| 1997 | 5 | 2 | 7 |
| 1998 | 3 | 3 | 6 |
| 1999 | 6 | 0 | 6 |
| 2000 | 5 | 1 | 6 |
| 2001 | 4 | 1 | 5 |
| 2002 | 5 | 3 | 8 |
| 2003 | 11 | 2 | 13 |
| 2004 | 6 | 4 | 10 |
| 2005 | 6 | 1 | 7 |
| 2006 | 1 | 3 | 4 |
| 2007 | 1 | 0 | 1 |
| 2008 | 2 | 1 | 3 |
| 2009 | 3 | 2 | 5 |
| 2010 | 2 | 0 | 2 |
| 2011 | 4 | 1 | 5 |
| 2012 | 3 | 1 | 4 |
| 2013 | 7 | 1 | 8 |
| 2014 | 1 | 2 | 3 |
| 2015 | 1 | 0 | 1 |
| 2016 | 3 | 0 | 3 |
| 2017 | 1 | 2 | 3 |
| 2018 | 1 | 0 | 1 |
| 2019 | 2 | 1 | 3 |
| 2020 | 0 | 2 | 2 |
| 2021 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
Below are the most recent publications written about "Dosage Compensation, Genetic" by people in Profiles.
-
Somatic XIST activation and features of X chromosome inactivation in male human cancers. Cell Syst. 2022 11 16; 13(11):932-944.e5.
-
De novo DNA methyltransferases DNMT3A and DNMT3B are essential for XIST silencing for erosion of dosage compensation in pluripotent stem cells. Stem Cell Reports. 2021 09 14; 16(9):2138-2148.
-
X-chromosome influences on neuroanatomical variation in humans. Nat Neurosci. 2021 09; 24(9):1216-1224.
-
Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation. Cell. 2020 07 09; 182(1):127-144.e23.
-
Spen links RNA-mediated endogenous retrovirus silencing and X chromosome inactivation. Elife. 2020 05 07; 9.
-
Evolutionary Dynamics of Sex Chromosomes of Paleognathous Birds. Genome Biol Evol. 2019 08 01; 11(8):2376-2390.
-
Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells. Genes Dev. 2019 08 01; 33(15-16):1031-1047.
-
Global Characterization of X Chromosome Inactivation in Human Pluripotent Stem Cells. Cell Rep. 2019 04 02; 27(1):20-29.e3.
-
Sex-Biased Gene Expression and Dosage Compensation on the Artemia franciscana Z-Chromosome. Genome Biol Evol. 2019 04 01; 11(4):1033-1044.
-
Sex-specific phenotypes of histone H4 point mutants establish dosage compensation as the critical function of H4K16 acetylation in Drosophila. Proc Natl Acad Sci U S A. 2018 12 26; 115(52):13336-13341.