"Decorin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A small leucine-rich proteoglycan that interacts with FIBRILLAR COLLAGENS and modifies the EXTRACELLULAR MATRIX structure of CONNECTIVE TISSUE. Decorin has also been shown to play additional roles in the regulation of cellular responses to GROWTH FACTORS. The protein contains a single glycosaminoglycan chain and is similar in structure to BIGLYCAN.
Concept/Terms
Decorin- Decorin
- Bone Proteoglycan II
- II, Bone Proteoglycan
- Proteoglycan II, Bone
- DSPG-II
Below are MeSH descriptors whose meaning is more general than "Decorin".
Below are MeSH descriptors whose meaning is more specific than "Decorin".
This graph shows the total number of publications written about "Decorin" by people in Harvard Catalyst Profiles by year, and whether "Decorin" was a major or minor topic of these publication.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 1997 | 0 | 2 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 0 | 3 | 3 |
| 2003 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
| 2007 | 0 | 1 | 1 |
| 2008 | 0 | 1 | 1 |
| 2010 | 0 | 1 | 1 |
| 2011 | 0 | 2 | 2 |
| 2013 | 2 | 1 | 3 |
| 2014 | 2 | 0 | 2 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2018 | 0 | 1 | 1 |
| 2019 | 0 | 1 | 1 |
| 2021 | 0 | 1 | 1 |
| 2022 | 1 | 0 | 1 |
Below are the most recent publications written about "Decorin" by people in Profiles.
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Myokine Expression and Tumor-Suppressive Effect of Serum after 12 wk of Exercise in Prostate Cancer Patients on ADT. Med Sci Sports Exerc. 2022 02 01; 54(2):197-205.
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Six-Month In Vivo Safety Profiling of Topical Ocular AAV5-Decorin Gene Transfer. Transl Vis Sci Technol. 2021 08 12; 10(10):5.
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Finding an Optimal Corneal Xenograft Using Comparative Analysis of Corneal Matrix Proteins Across Species. Sci Rep. 2019 02 12; 9(1):1876.
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Cross-ancestry genome-wide association analysis of corneal thickness strengthens link between complex and Mendelian eye diseases. Nat Commun. 2018 05 14; 9(1):1864.
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Asporin-deficient mice have tougher skin and altered skin glycosaminoglycan content and structure. PLoS One. 2017; 12(8):e0184028.
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Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model. Oncotarget. 2017 Jan 17; 8(3):4730-4746.
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Inhibition of Pediatric Glioblastoma Tumor Growth by the Anti-Cancer Agent OKN-007 in Orthotopic Mouse Xenografts. PLoS One. 2015; 10(8):e0134276.
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Decorin-expressing adenovirus decreases collagen synthesis and upregulates MMP expression in keloid fibroblasts and keloid spheroids. Exp Dermatol. 2015 Aug; 24(8):591-7.
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Cell cycle and apoptosis regulatory proteins, proliferative markers, cell signaling molecules, CD209, and decorin immunoreactivity in low-grade myxofibrosarcoma and myxoma. Virchows Arch. 2015 Aug; 467(2):211-6.
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Compensatory fetal membrane mechanisms between biglycan and decorin in inflammation. Mol Reprod Dev. 2015 May; 82(5):387-96.