Harvard Catalyst Profiles

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Darier Disease

"Darier Disease" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

An autosomal dominantly inherited skin disorder characterized by warty malodorous papules that coalesce into plaques. It is caused by mutations in the ATP2A2 gene encoding SERCA2 protein, one of the SARCOPLASMIC RETICULUM CALCIUM-TRANSPORTING ATPASES. The condition is similar, clinically and histologically, to BENIGN FAMILIAL PEMPHIGUS, another autosomal dominant skin disorder. Both diseases have defective calcium pumps (CALCIUM-TRANSPORTING ATPASES) and unstable desmosomal adhesion junctions (DESMOSOMES) between KERATINOCYTES.


This graph shows the total number of publications written about "Darier Disease" by people in Harvard Catalyst Profiles by year, and whether "Darier Disease" was a major or minor topic of these publication.
Bar chart showing 9 publications over 9 distinct years, with a maximum of 1 publications in 1994 and 1996 and 1997 and 1998 and 1999 and 2001 and 2006 and 2008 and 2013
To see the data from this visualization as text, click here.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.